Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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(1.97 ± 1.1 vs. 2.49 ± 1.0, p = 0.01) and higher amounts of
smoking (0.45 ± 0.5 vs. 0.16 ± 0.37) than T2D patients without
neuropathy. In addition, T2D patients with neuropathy had
significantly higher levels of HbA1C, microalbuminuria, and
urine albumin to creatinine ratio. In a multivariate logistic
regression model, smoking, HbA1C and presence of micro-
albuminuria were significantly associated with increased risk
of neuropathy in DM patients.
Conclusion: Decreased vegetable intake and habit of smoking
were lifestyle factors to develop neuropathy in T2D patients.
Therefore, daily vegetable intake and smoke cessation should
be strongly recommended in T2D patients.
PA-16
Insulin significantly changes the expression of T1DM mice’ s
circulating microRNA
Wen PAN1*, Jinhua YAN1, Jianping WENG1. 1The Third Affiliated
Hospital, Sun Yat-Sen University, China
Background and objective: the circulating miRNA spectrum of
patients with Type 1 Diabetic Mellitus (T1DM) is expected to
early screening and diagnosis, but the patients involved in the
clinic trial usually use the treatment of insulin, which needs us
to understand the influence of insulin to T1DM circulating
miRNA.
Method: We measured circulating miRNA expression by
microarray and quantitative RT-PCR in plasma samples of
streptozotocin (STZ)-treated C57BL/6 mice after 4 weeks
glargine intervention.
Result: compared with blank control group and diabetic
control group, insulin improves the expression of miR-320a
(1: 2.65: 10.71, p < 0.01), miR-26b (1: 1.42: 3.95, p < 0.05), let-7b (1:
2.88: 39.77, p < 0.01) in serum.
Conclusion: Confirmation of the change of TiDM circulating
miRNA by insulin is helpful for the early diagnosis of T1DM.
PA-17
The differences of metabolic syndrome in elderly subgroups: A
special focus on young-old, old-old and oldest old
Tsung-Ju CHUANG1, Chia-Luen HUANG1, Chien-Hsing LEE1,
Chang-Hsun HSIEH 1, Yi-Jen HUNG1, Chi-Feng HUNG1,
Yao-Jen LIANG 1, Yen-Lin CHEN1, Te-Lin HSIA 1, Dee PEI1*.
1 Division of Endocrinology and Metabolism, Department of Internal
Medicine, Tri-Service General Hospital, National Defense Medical
Center, Taipei
Background: Metabolic syndrome (MetS) is known to be
correlated to future diabetes and cardiovascular disease. Due
to the aging society, the increasing prevalence of MetS in the
elderly is an important health issue. However, there were few
studies focusing in this field. We investigated the changes of
MetS components in the subgroups of the elderly.
Methods: Subjects aged above 65 years old who underwent
routine health checkups in Taiwan (N = 18916) were divided
into three groups (young-old: ≧65 and < 75, old-old: ≧75 and
<85 and oldest-old ≧85). By using multiple logistic regressions,
the odds ratio (OR) of subjects with abnormal MetS compo-
nents to have MetS were evaluated.
Results: For men, the systolic blood pressure (SBP) and high-
density lipoprotein cholesterol increased as the age got older.
On the contrary, the diastolic blood pressure and triglycerides
(TG) decreased. In women, the waist circumference and SBP
increased significantly from the young-old to the oldest-old
groups. The highest percentage having MetS was 35% in old-
old men and 62% in oldest-old women. Finally, subjects with
high TG had the highest and BP had the lowest ORs for having
MetS in both genders except oldest-old women.
Conclusions: In the elderly, the MetS and its components have
different patterns not only in young-, old- and oldest-old
groups but also in men and women. Moreover, among the five
components, hypertension was always the most prevalent
one. Finally, subjects had high TG had the highest OR to have
MetS compared to other components.
PA-18
Diabetes nurse case management: Improving the health of
diabetes high-risk groups
Yu-lin YU1*. 1Feng Yuag Hospital, Taiwan
In recent years, diabetes prevalence has been gradually
increasing worldwide. This research was aimed to investigate
the effect of diabetes nurse case management for diabetes
high risk patients in improving their health self-management.
Methods: An observational method was adapted in this
research. The research was performed from Jan to Sep, 2015.
The study participants with high diabetes risks were referred
by the Endocrinology and Metabolic department or Family
Medicine department. The enrollment criteria include fasting
blood glucose (FBG) of 100∼ 125 mg/dL or total cholesterol of
>200 mg/dL. The participants were given 1 to 1 individualized
health education by a certified diabetes educator as a case
manager. The health education content include: intensive diet
and physical activity behavioral counseling program adhering
to the tenets of the Diabetes Prevention Program (DPP)
targeting loss of 7% of body weight and should increase their
moderate physical activity to at least 150 min/week. The
program was implemented for 6 months. The patients’ pre-
and post-intervention physical measurements, body mass
index (BMI), and waist circumference, blood pressures, and
blood biomarker levels were compared and their lifestyle
changes monitored.
Results: A total of 75 patients were enrolled in this study, with
31 male (41.3%), 44 female (58.6%), and an average age of
57.71 ± 10.85 years. After the study intervention, 44 (58.7%)
patients maintained moderate physical activity to at least
150 min/week, 17 (22.7%) patients achieved 90–150 min/week.
Most patients were determined with significant weight,
BMI, diastolic and systolic blood pressure, FBG, and total
cholesterol improvements (p < 0.05), yet, with no change in
waist circumferences.
Conclusion: The American Nation Institutes of Health
Diabetes Prevention Program (DPP) and the Finland Diabetes
Prevention Study (DPS) research team have reported that
intensive lifestyle modification programs are very effective in
the prevention or delay of type 2 diabetes. The research also
indicated that high diabetes risk cases can improve their
health conditions after the intervention of diabetes nurse case
management. Pay for performance has become a popular
approach to increase efficiency in health care. It is with hope
that pay for performance in Taiwan can be implicated in the
group of high risk for diabetes to increase the awareness of
chronic disease and promote the health of the pre-diabetes.
PA-19
Association of uric acid concentrations and metabolic
syndrome in Taiwan elderly population
Chia-Luen HUANG1, Yi-Jen HUNG1, Dee PEI2 , Yen-Lin CHEN3,
Chang-Hsun HSIEH1*. 1Division of Metabolism and Endocrinology,
Department of Internal Medicine, Tri-Service General Hospital,
National Defense Medical Center, Taipei, 2Department of Internal
Medicine, Cardinal Tien Hospital, School of Medicine, Fu-Jen Catholic
University, 3Department of Pathology, Cardinal Tien Hospital, School
of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan
Background: Currently, uric acid (UA) is not in the definition of
Metabolic syndrome (MetS), the positive correlation between
UA and MetS had been shown in several studies. The aging of
the general population becomes a major issue due to the
progress in the public health. However, the aforementioned
relationship between MetS and UA is not fully explored in
elderly group. To fill up the deficient piece of knowledge, we
enrolled age-difference groups in the Taiwanese elderly to
shed light on the relationships between UA levels and variable
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S70