Diabetes Research and Clinical Practice - Volume 120 - Supplement 1

PA-09

Gender differences in plasma growth arrest-specific protein 6

levels in adult subjects

Yi-Jen HUNG

*, Chien-Hsing LEE

, Yi-Shing SHIEH

Fu-Huang LIN

, Chang-Hsun HSIEH

Division of Endocrinology

and Metabolism, Tri-Service General Hospital, National Defense

Medical Center,

School of Dentistry, National Defense Medical

Center,

School of Public Health, National Defense Medical Center,

Taipei, Taiwan

Background:

Growth-arrest-speci

c 6 (Gas6) is recognized

as a secreted vitamin K-dependent protein, as it interacts

with receptor tyrosine kinases of the TAM (Tyro-3, Axl, Mer)

family. The plasma Gas6 are important to the inflammatory

process, and are involved in diverse human diseases. Few

studies have shown plasma Gas6 concentration varies with

genders. Hence, the aim of this study was to determine

whether plasma Gas6 levels are associated with sex hormones

in both genders.

Methods:

A total of 589 adult subjects, including 361 male and

228 female were recruited. Plasma Gas6 concentration, bio-

chemical, testosterone, estradiol (E2), sex hormone-binding

globulin were assayed. The index of free androgen (FAI) and

free E2 (FEI) were calculated.

Results:

Our results showed that significantly higher Gas6

levels were observed in adult male rather than female

(P < 0.05). In univariate regression analysis, plasma Gas6

levels were positively associated with FAI in male (

= 0.167,

P = 0.002) and both E2 and FEI in female (

= 0.384, P < 0.001 and

= 0.292, P < 0.001, respectively). Otherwise, Gas6 levels were

inversely associated with ages in both genders (

−

0.234,

P < 0.001 in male and

−

0.226, P = 0.001 in female, respect-

ively). Inmultivariate regression analysis, only age inmale and

E2 in female were independent variables to determine the

plasma Gas6 levels (

−

0.231, P = 0.002 and

= 0.458, P = 0.001).

Conclusions:

These results suggest that plasma Gas6 is

associated with sex hormones in female and ages in male,

indicating a potential role of sex hormones and ages involving

the Gas6/TAM system.

PA-10

Glucose-dependent insulinotropic peptide level is associated

with the development of type 2 diabetes mellitus

Sunghwan SUH

, Jeehyun LEE

, Ji Cheol BAE

, Sang-Man JIN

Hyun Jin KIM

, Jong Chul WON

, Sang Yong KIM

Nam Han CHO

, Moon-Kyu LEE

Dong-A University Medical

Center,

Pusan National University,

Samsung Changwon Hospital,

Sungkyunkwan University School of Medicine,

Samsung Medical

Center, Sungkyunkwan University School of Medicine,

Chungnam

National University School of Medicine,

Sanggye Paik Hospital,

College of Medicine, Inje University,

Chosun University Hospital,

Chosun University School of Medicine,

Department of Preventive

Medicine, Ajou University School of Medicine, Korea

Introduction:

Incretin hormone levels as a predictor of type 2

diabetes mellitus have not been fully investigated. Therefore,

we measured incretin hormone levels to examine the rela-

tionship between circulating incretin hormones, diabetes, and

future diabetes development in this study.

Materials and Methods:

A nested case-control study was

conducted in a Korean cohort. The study included the

following two groups: the control group (n = 149), the incident

diabetes group (n = 65). Fasting total glucagon-like peptide-1

(GLP-1) and total glucose-dependent insulinotropic peptide

(GIP) levels were measured and compared between these

groups.

Results:

Fasting total GIP levels were higher in the incident

diabetes group than in the control group (32.64 ± 22.68 pmol/L

vs. 25.54 ± 18.37 pmol/L, P = 0.034). There was no statistically

significant difference in fasting total GLP-1 levels between

groups (1.14 ± 1.43 pmol/L vs. 1.39 ± 2.13 pmol/L, P = 0.199). In

multivariate analysis, fasting total GIP levels were associated

with an increased risk of diabetes (odds ratio, 1.005; P = 0.012)

independent of other risk factors.

Conclusion:

Fasting total GIP levels may be a risk factor for the

development of type 2 diabetes mellitus. This association

persisted even after adjusting for other metabolic parameters

such as elevated fasting glucose, hemoglobin A1c, and obesity

in the pre-diabetic period.

PA-11

The relationship between body composition, glycemic index,

and glycemic response of foods in healthy Indonesian adults

Kamalita PERTIWI

*, Ardy Brian LIZUARDI

, Astri KURNIATI

Lina ANTONO

, Susana XIE

, Vanessa YOLANDA

PT. Nutrifood Indonesia, Indonesia

Previous study showed that body composition could influence

glycemic response in healthy subjects. However, only a small

number of respondents were included in the study. The

objective of the current research was to study the relationship

between body composition, glycemic index, and glycemic

response of food in healthy Indonesian adults. Seventy-eight

adults (BMI: 22.8 ± 3.4 kg/m

) were recruited to participate in

the study. Body weight and composition were determined by

body composition analyzer (Inbody 720). Capillary finger stick

blood sample were analyzed for glucose concentration at

−

15, 30, 45, 60, 90, and 120 minutes and the resulting 2 h iAUCs

following consumption of a 50-grams glucose beverage and

noodles in two separated days were calculated. Study results

were analyzed in different BMI and gender categories. The

current study showed that glycemic index of noodles was not

correlated with body composition. However, skeletal muscle

mass (SMM) was negatively correlated with iAUC of glucose

(r:

−

0.29, P: 0.009). In overweight subjects (n = 9) (BMI 23.0

–

25.0 kg/m

), a strong significant negative correlation between

iAUC of glucose and waist-to-hip ratio (WHR) (r:

−

0.83, P: 0.006)

was observed. In obese subjects (n = 19) (BMI > 25.0 kg/m

iAUC of glucose was moderately positively correlated with

visceral fat (r: 0.59, P: 0.007) and iAUC of noodles was

moderately positively correlated with WHR (r: 0.61, P: 0.005).

Subgroup analysis showed that iAUC of glucose and noodles

were negatively correlated with SMM (r:

−

0.42 and

−

0.37, P: 0.01

and 0.024) only in male adults (n = 37). However, there was no

correlation observed between body composition to glycemic

response of foods in female adults. This study showed that

muscle mass might be a potential determinant of glycemic

response of food in Indonesian adult subjects.

PA-12

Chronic kidney disease and peripheral artery disease in type 2

diabetes

Chih-Hsun CHU

*, Chun-Chin SUN

, Wan-Chi CHUANG

Wei-Cheng CHANG

, Yu-Hsuan TSAI

, Wang-Jung KAO

Division of Endocrinology and Metabolism, Department of Internal

Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Background:

To examine the association of chronic kidney

disease (CKD) with the peripheral artery disease (PAD) in type 2

diabetic subjects.

Materials and methods:

A total of 212 type 2 diabetic patients

(64 ± 13 years, 135 males) were enrolled and divided into

two groups: one with a presence of CKD (eGFR < 60 mL/min/

1.73 m

, n = 74) or one without (n = 138). We recorded clinical

and biochemical data as well as ankle brachial index (ABI) for

comparisons. Data are reported as mean ± SD.

Results:

The patients with CKDwas older and had had diabetes

mellitus (DM) longer, had higher systolic blood pressure (BP),

higher albumin to creatinine ratio (ACR) than those without

CKD. The patients with CKD also had more prevalence of

hypertension and dyslipidemia. Lower mean ABI was noted in

those with CKD than without (1.08 ± 0.15 vs 1.14 ± 0.10, p =

0.001). The occurrence of PAD (defined as one ABI < 0.9) was

Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65

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