Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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Poster Presentations
Early Screening and Intervention of
Prediabetes and Diabetes
PA-01
The impact of age on fasting plasma glucose-based screening
algorithms for gestational diabetes mellitus
Chun-Heng KUO 1, Szu-Chi CHEN1, Feng-Jung NIEN2,
En-Tzu WU 3, Shin-Yu LIN6, Lee-Ming CHUANG4,5,
Chien-Nan LEE6, Hung-Yuan LI4*. 1Department of Internal
Medicine, New Taipei City Hospital, New Taipei City, 2Department of
Internal Medicine, National Taiwan University Hospital, Yun-lin
branch, Yun-lin 3Department of Obstetrics and Gynecology, Dianthus
MFM Clinic, 4 Department of Internal Medicine, National Taiwan
University Hospital, 5Institute of Preventive Medicine, College of Public
Health, National Taiwan University, 6Department of Obstetrics and
Gynecology, National Taiwan University Hospital, Taipei, Taiwan
Objective: Screeningmethods based on fasting plasma glucose
(FPG) have been proposed to reduce oral glucose tolerance tests
(OGTT) in the diagnosis of gestational diabetes mellitus (GDM)
by the IADPSG criteria. Since these methods are developed in
countries where women get pregnant at younger ages, they
may not be applicable in countries where women get pregnant
at older ages. In this study, we investigated the impact of
maternal age on diagnosis of GDM.
Research design and methods: In 2011, 948 pregnant women
who received a 75 g OGTT to diagnose GDM at National Taiwan
University Hospital were included. FPG-based screening
algorithms considering age or not were developed. Another
375 pregnant women were recruited in 2013–2015 as a
validation cohort for the algorithms.
Results: Using FPG criteria only, more GDM were missed in
women ≥ 35 years old than in women <35 years old (13.3%
vs. 5.8%, p < 0.001). AmongGDMwomen ≥35 years old, 62.5%had
normal FPG. The sensitivity, specificity, and the percentage of
womenwho receivedOGTT (OGTT%) of the FPG-based screening
algorithm were 92.1%, 100%, and 77.6%, respectively. Another
algorithm was developed with age-specific cutoffs for FPG,
which reduced OGTT% to 59.2%, with good sensitivity (91.3%)
and specificity (100%). Similar reduction in OGTT%was found in
the validation cohort (87.0% to 70.1%). In the simulation, if the
percentage of women ≥35 years old were between 30% and 70%,
algorithms considering age can reduce OGTT% by 15.4 –19.9%.
Conclusions: Algorithms considering age can reduce the need
of OGTT in the diagnosis of GDM.
PA-02
Improvement on risk factors of metabolic syndrome by
community activities in small to medium hospital-study from
local hospital in Kaohsiung
Shan-Sian YU 1*, Jia-Ru LIN1, Chia-Yin LIAO1, Chao-Liang SUN 1.
1 Kaohsiung Municipal Feng-Shan Hospital, Taiwan
Objective: Metabolic syndrome is a cluster of conditions
included high blood pressure, high fasting blood sugar,
abnormal cholesterol and obesity. The more risk factors in
metabolic syndrome, the higher morbidity occurred in cardio-
vascular diseases and diabetes mellitus. In 2014, the major
diseases among the top ten leading causes of death were
chronic diseases such as heart diseases, diabetes mellitus and
cerebrovascular diseases in Taiwan. The prevalence of meta-
bolic syndrome in population of age over 20-year-old is 19.7%.
This study aimed to connect the small to medium hospital
with diversified community activities to improve life patterns
and decrease metabolic syndrome.
Methods: We recruited participants with metabolic syndrome
from the medical examination center, screen activities,
inpatients and outpatients. The participants were randomized
to experiment group and control group. Community activities
were provided for experiment group. The biochemistry test
and satisfaction of the community activities were collected
after the intervention.
Results: The analysis was done using SPSS 12.0 statistical
package. The satisfaction of the community activities was
92.7%. In the experiment group, the systolic blood pressure
(decreased 21.61 ± 17.81 mmHg), the fasting blood sugar
(decreased 21.49 ± 32.26 mg/dL) and triglyceride (decreased
87.33 ± 194.58 mg/dL) showed significantly improvement. The
waistline of female participants decreased 4.11 ± 3.59 cm and
6.08 ± 3.90 cm in male participants. In control group, systolic
blood pressure (decreased 5.87 ± 21.2 mmHg), triglyceride
(decreased 36.94 ± 122.98 mg/dL) and high-density lipoprotein
(increased 3.59 ± 6.12 mg/dL) showed the significance. There
are significantly improved in systolic blood pressure, trigly-
ceride and the waistline of both male and female participants
between experiment and control group.
Conclusions: After the diversified community activities in
experiment group, the risk factors of metabolic syndrome such
as blood pressure, fasting blood sugar, triglyceride and
waistline improved significantly. It is effective for the small
to medium hospital to connect with the diversified com-
munity activities to improve the risk factors of metabolic
syndrome.
PA-03
Effects of exercise program on normal responsiveness of
serum GDF15 in middle-aged women
Kyong Hye JOUNG1, Ji Min KIM1, Hyon-Seung YI 1, Ju Hee LEE1,
Koon Soon KIM1, Hyun Jin KIM1, Minho SHONG1 ,
Bon Jeong KU1*. 1Department of Internal Medicine, Chungnam
National University Hospital, Daejeon, Korea
Background: Protective effects of exercise on the chronic
inflammatory disease such as metabolic disease and cardio-
vascular disease is emerging as one of very important field
of medical research. Growth differentiation factor 15 (GDF15)
is well-known as stress-induced cytokine association with
metabolic disease. GDF15 play a role in body weight by higher
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