Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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OL10-5
The role of irisin in components of metabolic syndrome,
insulin secretion and resistance in schoolchildren
Chung-Ze WU1,2, Jin-Shuen CHEN3, Li-Chien CHANG4,
Yuh-Feng LIN 5,6, Dee PEI7, Nain-Feng CHU8,9 . 1Division of
Endocrinology and Metabolism, Department of Internal Medicine,
Shuang Ho Hospital, Taipei Medical University, 2Department of
Internal Medicine, School of Medicine, College of Medicine, Taipei
Medical University, 3Division of Nephrology, Department of Internal
Medicine, Tri-service, General Hospital, National Defense Medical
Center, 4National Defense Medical Center, School of Pharmacy,
5 Graduate Institute of Clinical Medicine, College of Medicine, Taipei
Medical University, 6Department of Internal Medicine, Shuang Ho
Hospital, Taipei Medical University, 7School of Medicine, College of
Medicine, Fu Jen Catholic University, 8Superintendent, Taitung
Hospital, Ministry of Health and Welfare, 9National Defense Medical
Center, School of Public Health, Taiwan
Background: The prevalence of obesity worldwide has
increased rapidly in recent decades, leading to increased
morbidities and mortalities. Different from white adipose
tissue, brown and beige adipose tissues contain abundant
mitochondria, and help burn energy and create non-shivering
thermogenesis. Enriching brown and beige adipose tissue may
have potential as an anti-obesity strategy. Irisin, shaved from
fibronectin type III domain containing 5 (FNDC5) in muscle
tissue, increases after exercise and is believed to be the
crucial factor in converting white adipose tissue to beige
adipose tissue. In the present study, we explored the relation-
ship between irisin levels and components of metabolic
syndrome, fibrinolytic proteins, insulin secretion and resist-
ance in schoolchildren in Taiwan.
Methods: Therewere 369 children (172 boys and 197 girls), aged
10.3 ± 1.5 years, enrolled from Taiwan elementary schools in
our study. Irisin, anthropometry, metabolic syndrome compo-
nents, insulin secretion, and resistance were measured.
Subjects were divided into normal, overweight, and obese
groups for evaluation of irisin in obesity. Finally, the relation-
ship between irisin level and metabolic syndrome in boys and
girls was analyzed.
Results: In boys, irisin levels were not associated with BMI
percentile, body fat, blood pressure, lipid profiles, insulin
secretion or resistance. The irisin levels in boys were asso-
ciated, however, with age and fasting plasma glucose. After
adjusting for age, the irisin level in boys was negatively related
to fasting plasma glucose (r = −0.21, p = 0.006) and weakly
positively related to soluble plasma activator receptors (r =
0.135, p = 0.046). In girls, the irisin levels were associated with
age and body fat. However, after adjusting of age, the irisin
levels in girls were only positively related to fasting plasma
glucose (r = 1.49, p = 0.038). In both genders, irisin levels were
similar among normal, overweight, and obese groups, and
between subjects with and without metabolic syndrome.
Conclusion: The irisin levels were not associated with meta-
bolic syndrome and obesity in either boys or girls in Taiwan.
However, we found that the irisin levelswere negatively related
to fasting plasma glucose in boys and positively related to
fasting plasma glucose in girls. The contrary relationship
between irisin and fasting plasma glucose in boys and girls
needs further exploration in the future.
OL10-6
Association between 1,5-anhydroglucitol and early-phase
insulin secretion in Chinese patients with newly diagnosed
type 2 diabetes mellitus
Jian ZHOU 1, Xiaojing MA1, Hang SU1, Yaping HAO1, Xiang HU 1,
Yuqi LUO1, Zixuan DENG1, Yuqian BAO1, Weiping JIA1.
1 Department of Endocrinology and Metabolism, Shanghai Jiao Tong
University Affiliated Sixth People’s Hospital, Shanghai Clinical Center
for Diabetes, Shanghai Diabetes Institute, Shanghai, China
Objective: Glucose monitoring plays a key role in comprehen-
sive management of diabetes. Insulin secretion deficiency and
insulin resistance are involved in both the onset and progres-
sion of diabetes mellitus. The goal of this study was to probe
into the relationships of glycated hemoglobin A1c (HbA1c) and
1,5-anhydroglucitol (1,5-AG) with insulin sensitivity and
secretion in patients who were newly diagnosed with type 2
diabetes mellitus.
Methods: A total of 302 patients with newly diagnosed type 2
diabetes mellitus (166 men and 136 women; age range, 27– 79
years old) were enrolled in this study. The homeostasis model
assessment of insulin resistance (HOMA-IR) and homeostasis
model assessment of β cell function (HOMA-β) were calculated
to evaluate the basal insulin sensitivity and secretory function,
respectively. Insulinogenic index (IGI) was used for assess-
ment of early-phase insulin secretion. HbA1c was detected by
high-performance liquid chromatography. Serum 1,5-AG was
assayed using the enzymatic method.
Results: When the subjects were stratified according to HbA1c
quartiles, the trends analyses showed an upward trend
for HOMA-IR and downward trends for both HOMA-β and IGI
with increasing HbA1c quartiles (all P for trend <0.001).
Increased 1,5-AG quartiles were accompanied by a decreasing
trend in HOMA-IR and increasing trends in HOMA-β and IGI
(all P for trend <0.001). Multiple stepwise regression analysis
revealed that the independent correlations of HOMA-IR
(standardized β = 0.525) and HOMA-β (standardized β = – 0.673)
with HbA1c were present (both P < 0.001) when HbA1c was
defined as the dependent variable. Moreover, 1,5-AG was not
only independently associated with HOMA-IR and HOMA-β
(standardized β = –0.349 and 0.232, both P < 0.01), but also
exhibited an independent and positive association with IGI
(standardized β = 0.242, P < 0.001).
Conclusions: 1,5-AG level was not only correlated with basal
insulin sensitivity and secretion, but also closely associated
with early-phase insulin secretion in Chinese patients with
newly diagnosed type 2 diabetes mellitus.
OL10-7
Increases in urinary N-acetyl-β-D-glucosaminidase excretion
are associated with increased arterial thickness and presence
of carotid plaques in type 2 diabetes
So Ra KIM1, Gyuri KIM1, Ji-Yeon LEE1, Yong-ho LEE 1,
Eun Seok KANG1, Bong-Soo CHA1, Byung-Wan LEE1*.
1Department of Internal Medicine, Yonsei University College of
Medicine, Seoul, Korea
N-acetyl-β-D-glucosaminidase (NAG) present in high concen-
tration in lysosomes of proximal renal tubular cells is released
into the urine after renal proximal tubule injury. Recently,
urinary NAG has gained considerable attention because of its
clinical implications as a sensitive and specific biomarker
for early stage diabetic kidney disease. Several studies on
associations between urinary NAG and micro-/macrovascular
complications of diabetes have been reported. However, there
is no data on association between urinary NAG and carotid
intima media thickness (IMT) in patients with type 2 diabetes
mellitus (T2D). The aim of this study was to investigate
whether increases in urinary NAG are associated with arterial
atherosclerosis assessed by carotid IMT. In this retrospective
cross-sectional study, a total of 343 participants with T2D
who had been tested for urinary NAG, carotid IMT, and
gluco-metabolic parameters were enrolled. Demographic
factors including age, sex, body mass index, smoking habit,
blood pressure, duration of diabetes, and history of cardiovas-
cular events were recorded. Mean age and duration of diabetes
were 59.9 and 11.6 years, respectively. The participants with
above median level of urinary NAG (11.4 (8.72–16.7) U/gCr)
showed significantly higher values of mean and maximum
carotid IMT (0.72 (0.60–0.84) vs 0.67 (0.58 –0.77) mm and 0.90
(0.74–1.06) vs 0.82 (0.70–0.97) mm, respectively) than
Oral Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S40–S64 S63