Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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Background: Individuals whose 2 h plasma glucose (2hPG)
levels did not return to their fasting plasma glucose (FPG)
level (2hPG > FPG), increased risk of cardiovascular dis-
eases than those whose 2hPG did (2hPG FPG) during an oral
glucose tolerance test in Europeans. However, the risk for
cardiovascular risk was not well known in Chinese. We will
assess the risk for and prevalence of cardiovascular diseases
(CVD) in relation to FPG and 2hPG levels within normoglycemic
range in Chinese population.
Methods: Data from Qingdao Diabetes Prevention Program
comprising 1687 men and 2568 women aged 35 –74 years who
had FPG < 6.1 mmol/L and 2hPG < 7.8 mmol/L was analysed in
the current study. Multivariate-adjusted odds ratios (ORs) and
95% confidence interval (95% CI) for prevalence of CVD was
estimated for individuals whose 2hPG > FPG as compared
with those whose 2hPG ≤ FPG, controlling for age, BMI, total
cholesterol, uric acid, triglycerides, smoking status, drinking
status, frequency of vegetable and fruit consumptions.
Results: A total of 829 (986) individuals was classified as CVD in
men (women). The prevalence of CVD was significantly higher
in the Group II than in the Group I (P < 0.01). The individuals
from the Group II was older and had higher BMI, diastolic blood
pressure, total cholesterol, triglycerides, uric acid and insulin
resistance than those in the Group I (P < 0.01 for all compar-
isons). The multivariate-adjusted ORs (95%CIs) for prevalence
of CVDwas 1.23 (1.06 –1.42), 1.07 (1.06–1.08), 1.17 (1.14–1.19) and
1.43 (1.16–1.77) for Group II vs. Group I, age, BMI and drinking
status, respectively. The ORs (95%CIs) for prevalence of CVD
was also significant difference after additional adjustment for
insulin resistance, vegetable and fruit intake in a subgroup of
individuals.
Conclusions: In individuals with both FPG and 2hPG within
normoglycemic range, high 2hPG was significantly associated
with insulin resistance and increased risk of CVD. Studies are
warranted to evaluate the causal relevance of these findings.
PA-27
The correlation of diabetic status, ischemic and atrophic
burdens and cognitive decline in diabetic patients with
cognitive impairment
Jay Cheol KWON 1*, Sung Rae CHO1, Gwi Hwa JUNG1.
1 Department of Neurology, Changwon Fatima Hospital, Korea
Background: Although the increasing number of clinical
researches about diabetes and cognition, many limitations
and debates have been exposed and yet revealed little. Also the
contribution of Alzheimer-type and/or vascular pathology to
cognitive declines has been remained unclear. The aim of this
study was to evaluate the contributing factors correlated with
cognitive declines in selected diabetic patients with cognitive
impairments prospectively.
Methods: After interviewing 286 diabetic patients using
dementia screening questionnaire in their 7thdecades, we
enrolled 49 subjects who have cognitive impairment (age =
64.76 ± 3.27 (61–70), M:F = 26:23, education = 7.74 ± 4.53 years,
K-MMSE = 25.37 ± 3.92, MoCA = 18.24 ± 4.69). Korean version
mini-mental status examination (K-MMSE), MoCA and
several laboratory examination of diabetes and lipid were
tested and repeated after 6 and 12 months. All subjects were
performed Brain MRI and scored visually focusing ischemia
and atrophy.
Results: The fluctuation index of fasting blood glucose (FBS)
and glycosylated hemoglobin (HbA1c) were negatively corre-
lated with cognitive change (p = 0.01, p = 0.02). And low density
lipoprotein (LDL) level was negatively correlatedwith cognitive
change (p = 0.02) but high density lipoprotein (HDL) was
positively (p = 0.03). MRI factors focusing on white matter
hyperintensities and medial temporal atrophy are not signifi-
cantly correlated with cognitive declines.
Conclusions: We concluded the fluctuation rather than mean
value of blood glucose level are the possible predictor of
cognitive declines in diabetic patients and suggested manage-
ment strategy. There is a need for larger, quantitative, clinical-
neuroimaging studies to improve knowledge of the complex
contributions by vascular and Alzheimer pathologies in
diabetic patients.
PA-28
Relationship between glycated albumin and glycated
hemoglobin according to glucose tolerance status: A
multicenter study
Yifei MO1, Xiaojing MA1 , Hong LI2, Xingwu RAN 3,
Wenying YANG4, Qiang LI5, Yongde PENG6, Yanbing LI7 ,
Xin GAO8, Xiaojun LUAN9, Weiqing WANG10, Yun XIE11,
Jian ZHOU1, Weiping JIA1*. 1Department of Endocrinology and
Metabolism, Shanghai Jiao Tong University Affiliated Sixth People
Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes
Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai
Key Clinical Center, 2Department of Endocrinology and Metabolism,
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University,
Hangzhou, 3Department of Endocrinology and Metabolism, West
China Hospital, Sichuan University, Chengdu, 4Department of
Endocrinology and Metabolism, China-Japan Friendship Hospital,
Beijing, 5Department of Endocrinology and Metabolism, The Second
Affiliated Hospital of Harbin Medical University, Harbin,
6Department of Endocrinology and Metabolism, Shanghai Jiao Tong
University Affiliated First People’s Hospital, Shanghai, 7Department
of Endocrinology and Metabolism, The First Affiliated Hospital of Sun
Yat-Sen University, Guangzhou, 8Department of Endocrinology and
Metabolism, Fudan University Affiliated Zhongshan Hospital,
Shanghai, 9Department of Endocrinology and Metabolism, The First
People’s Hospital of Foshan, Foshan, 10Shanghai Clinical Center for
Endocrine and Metabolic Diseases, Shanghai Institute of
Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong
University School of Medicine, Shanghai, 11 Department of Diabetic
Neurology, Metabolic Disease Hospital, Tianjin Medical University,
Tianjin, China
Aims: To determine the relationship between glycated
albumin (GA) and glycated hemoglobin (HbA1c) and to
explore the association of glycated albumin/glycated hemo-
globin (GA/HbA1c) ratio with glucose indices in Chinese
subjects with different glucose tolerance status.
Methods: The hospital-based, cross-sectional study involved
953 participants without known diabetes from 11 centers in
China. Oral glucose tolerance test (OGTT) was used to identify
three groups of subjects: normal glucose regulation (n = 194),
impaired glucose regulation (n = 303) and newly diagnosed
type 2 diabetes group (n = 456). The GA, HbA1c and GA/HbA1c
ratio were tested.
Results: GA was positively correlated with HbA1c (r = 0.832,
P < 0.001). After correcting for age, sex and BMI, the correlations
remained significant (r = 0.824, P < 0.001). Linear regression
analysis estimated that a 1% increase of HbA1c was associated
with a 2.84% increase of GA (GA = 2.843 × HbA1c–0.203;
R2 = 0.692, P < 0.001). GA would be 18.3 (16.7–19.9) % and 19.7
(18.0–21.4) % with HbA1c of 6.5% (48 mmol/mol) and 7.0%
(53 mmol/mol). The mean GA/HbA1c ratio was 2.81 ± 0.38, and
it significantly increased with the presence of glucose intoler-
ance (all, P < 0.05). In the total study population, GA/HbA1c was
correlated with BMI, glucose levels and 30-min insulin during
OGTT, the homeostaticmodel assessment of beta-cell function
(HOMA-beta), and ΔI30/ ΔG30 (all, P < 0.05). Increased glucose at
30 min (standardizedbeta = 0.221, P < 0.001), anddecreasedBMI
(standardized beta = −0.114, P = 0.008) were associated with
elevatedGA/HbA1c ratiobymultiple linear regression (adjusted
R2 = 0.045).
Conclusions: The relationship between GA and HbA1c was
strong. The GA/HbA1c ratio was related to acute postprandial
glucose excursion and BMI level.
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S73