Diabetes Research and Clinical Practice - Volume 120 - Supplement 1

increased waist circumference are associated with insulin

resistance as measured by the Matsuda index and can be used

as clinical markers to indicate that a patient should undergo

OGTT. In addition, increased insulin sensitivity is associated

with better metabolic profile as reflected by lower levels of

triglycerides, LDL and higher HDL.

PA-36

Reduced complexity of glucose dynamics is associated with

poor control patients among patients with type 2 diabetes

Jin-Long CHEN

1,2

*, Pin-Fan CHEN

Department of Medical

Informatics, Tzu Chi University,

Institute of Medical Sciences, Tzu

Chi University, Hualien,

Division of Endocrinology and Metabolism,

Department of Internal Medicine, Dalin Tzu Chi Hospital, Chiayi,

Taiwan

Chronic sustained hyperglycemia has been shown to play an

important role in the formation of diabetic complications.

However, emerging evidences have suggested that acute

fluctuating hyperglycemia contribute to these complications.

Continuous glucose monitoring system (CGMS) is a useful tool

to monitor the blood glucose fluctuation in diabetes.

Complexity index (CI) derived from multiscale entropy (MSE)

analysis has recently been shown to be a new parameter for

the evaluation of blood glucose fluctuation in patients with

diabetes receiving CGMS recording. In addition, the diabetic

patients revealed a significant decrease in the MSE CI

compared with the control subjects, indicating a decreased

complexity of glucose dynamics in the diabetic patients. No

study has investigated the MSE analysis among moderate and

poor control diabetes. This study was designed to compare the

complexity of glucose dynamics between moderate and poor

control type 2 diabetes (T2D). Twenty moderate control and 25

age- and BMI-matched poor control patients with T2D were

evaluated retrospectively from CGMS data recorded in a

teaching hospital. Compared with moderate control patients,

the poor control patients revealed a significant increase

(P < 0.05) in the mean (poor control 190.7 ± 5.8 vs. moderate

control 160.0 ± 6.2 mg/dL), the standard deviation (58.3 ± 2.7 vs.

46.3 ± 3.1 mg/dL), and the mean amplitude of glycemic excur-

sions (138.4 ± 6.9 vs. 114.0 ± 6.9 mg/dL); and a significant

decrease (P < 0.05) in the MSE CI (4.85 ± 0.23 vs. 5.45 ± 0.22). In

conclusion, these findings show that the poor control diabetic

patients manifest a greater fluctuating blood glucose profile

and an increased regularity of blood glucose fluctuating

pattern compared with the moderate control diabetic patients.

Moreover, MSE CI could potentially be used as a biomarker in

the monitoring of diabetes.

PA-37

The effect of medical nutrition therapy in diabetic patients

with early chronic kidney disease

Chiao-Yu WAN

, Te-Shu WU

, Ya-Wen HUANG

Hsiao-Lien CHEN

*, Tzu-Ling CHEN

, Yu-Hsien CHANG

Department of Dietician, Lo-Hsu Medical Foundation, Lotung Poh-Ai

Hospital,

Division of Endocrinology and Metabolism, Department of

internal medicine, Lo-Hsu Medical Foundation, Lotung Poh-Ai

Hospital, Taiwan

Introduction:

Diabetic nephropathy is a diabetic complication

characterized by albuminuria, increased blood pressure and a

relentless decline in renal function. It is the fourth leading

cause of death in Taiwan. The aim of this study is evaluate the

effect of medical nutrition therapy (MNT) in diabetic patients

with early chronic kidney disease.

Methods:

A total of one hundred eighteen diabetic patients

with early CKD received MNT were included. Patients were

divided into two groups: (1) <65 years and (2)

≧

65 years. Data

including weight, blood pressure, glomerular filtration rate

(eGFR), serum creatinine, LDL, HbA1c and microalbuminuria

were analyzed by retrospective review of the medical records.

All patients were at least received MNT and followed up four

times.

Results:

There were significantly reductions in body weight

(P = 0.022) and systolic blood pressure (P = 0.050) in all patients

but not significant differences in microalbuminuria, serum

creatinine and eGFR. There is also significant reduce in HbA1c

(P = 0.032) of <65 year-old patient group.

Conclusion:

Our study showed that MNT for diabetic patient

with early CKD can improve body weight and systolic blood

pressure in our study patients.

Diabetes Management: Gene and

Environment

PB-01

Two-year efficacy and safety of moderately-low-carbohydrate

diet

Satoru YAMADA

*, Mariko SHIMADA

, Mitsuhisa TABATA

Hisa IZUMI

, Chikako NAKAJIMA

, Junichi UCHIDA

Junichiro IRIE

Kitasato Institute Hospital, Japan

Recently, many scientific organizations recommend moder-

ately low-carbohydrate diet (MLCD) (Diabetes Care 2013)

(Lancet 2014). In East-Asian population, we first reported the

efficacy of MLCD in randomized controlled trial (Intern Med

2014). In this study, we assessed the 2 year efficacy and safety

of MLCD (70

–

130 g/d) in Japanese type 2 diabetes. Two hundred

type 2 diabetic patients who were advised MLCD were enrolled

and 160 patients were followed for 2 years (drop-out 23, move

14, death 3). Glycemic control, body mass index (BMI), lipid

profiles, liver enzymes and dose of antidiabetic drugs were

assessed at baseline and after 2 years. During the 2-year

follow-up period, HbA1c levels were significantly improved

(baseline: 8.0 ± 1.5%, 2-year: 7.4 ± 1.2%, p < 0.0001), and ALT also

decreased significantly (baseline: 30.1 ± 23.4 mg/dL, 2-year:

25.2 ± 18.6 mg/dL, p = 0.003). Body weight, LDL-C, TG, HDL-C,

AST, SBP, and DBP showed non-significant improvement. UA

(baseline: 5.8 ± 1.5 mg/dL, 2-year: 5.8 ± 1.4 mg/dL) and Cr (base-

line: 0.8 ± 0.2 mg/dL, 2-year: 0.8 ± 0.2 mg/dL) did not change

and UN slightly increased (baseline: 15.9 ± 5.2 mg/dL, 2-year:

17.0 ± 5.4 mg/dL, p < 0.05). Our results suggest long-term effi-

cacy and safety of MLCD in East-Asian population.

PB-02

Comparison of epidemiological, clinical, laboratory and

radiological features of diabetic and non-diabetic patients with

pulmonary tuberculosis at Calmette Hospital, Cambodia

Satha SUM

1,2

*, Videm CHEA

, Sarin CHAN

1,2

Sophoeun NHEM

1,2

Calmette Hospital,

University of Health

Sciences, Cambodia

Background:

As the global prevalence of diabetesmellitus (DM)

increases, especially in low-to-middle income countries such

as Cambodia where tuberculosis (TB) remains endemic, we

will encounter a growing number of TB patients with DM.

Diabetes mellitus (DM) due to suppressive effect on cellular

immunity can impact on progression of tuberculosis (TB).

Objectives:

The aim of this study was to investigate the impact

of DM on the epidemiological, clinical, and biological and chest

x-ray of pulmonary TB patients.

Patients andmethods:

In this retrospective study, the informa-

tions of 120 admitted pulmonary TB patients with BK (+) in

Medicine A and A4 ward of Calmette hospital in Phnom Penh

from 1st January 2014 to 31st December 2015 were extracted

from their medical files. The patients were divided into two

groups as TB with DM (n = 56) and TB without DM (n = 64). The

related data on epidemiology, signs, symptoms, biological

tests, radiology and sputum smear or bronchoaveolar lavage

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