Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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Results: sVAP-1 was associated negatively with body mass
index (BMI, r = − 0.1449, p = 0.003), waist circumference (r =
− 0.1425, p = 0.004), visceral (r = −0.1457, p = 0.003) and subcuta-
neous (r = −0.1025, p = 0.035) abdominal fat areas, and serum
C-reactive protein (r = − 0.2035, p < 0.0001), and positively with
plasma adiponectin (r = 0.2086, p < 0.0001) and aldosterone
(r = 0.1018, p = 0.041), adjusted for age and gender. After
4.7 ± 2.6 years, 73 subjects (12.2%) developed incident diabetes.
Subjects with sVAP-1 in the highest tertile showed the lowest
incidence of diabetes, adjusted for age and gender. Every 1
standard deviation increase in sVAP-1 was associated with a
34% decrease in the risk of incident diabetes (HR = 0.66, 95%
CI = 0.5–0.88, p < 0.01), adjusted for age, gender, BMI, family
history of diabetes, hemoglobin A1c, HOMA2%B, and
HOMA2-IR.
Conclusions: Serum VAP-1 is associated with obesity nega-
tively. High sVAP-1 predicts a lower incidence of diabetes in
human.
PA-32
Vegetarian diet lowers the incidence of diabetes in a
Taiwanese Buddhist population
Tina H.T. CHIU 1,2*, Wen-Harn PAN2,3, Chin-Lon LIN1,
Ming-Nan LIN 4. 1Buddhist Tzu Chi Medical Foundation, 2Graduate
School of Epidemiology and Preventive Medicine, 3Institute of
Biomedical Science, Academia Sinica, 4Department of Family
Medicine, Buddhist Dalin Tzu Chi Hospital, Taiwan
Objective: Vegetarian diet has been shown to reduce risk of
diabetes in Western populations, but its impact on high risk
Asians is unknown.
Aim: To examine the effect of vegetarian diet on occurrence of
diabetes within a prospective cohort study.
Methods: We followed 2568 non-smoking, non-alcohol
drinking Buddhists free of diabetes at baseline. All participants
completed a validated food frequency questionnaire in
addition to having fasting blood glucose tested at baseline.
Dietary pattern, fasting glucose, and HbA1C were assessed at
follow-up. Multiple logistic regression was used to assess the
effect of diet on diabetes, adjusting for age, gender, education,
family history of diabetes and BMI.
Results: In the 5 years of follow-up, 222 new cases of diabetes
were identified. 991 vegetarians and 907 non-vegetarians
stayed consistent with their diet pattern, while 74 baseline
vegetarians reverted to non-vegetarians (the reverted), 596
non-vegetarians converted to vegetarians (the converted). We
found lower risk of diabetes in consistent vegetarians (OR: 0.66,
95% CI: 0.48, 0.93) and the converted (OR: 0.59, 95% CI: 0.39,
0.88), compared with consistent non-vegetarians.
Conclusion: Taiwanese vegetarian diet is associated with
lower risk for diabetes, independent of BMI.
PA-33
The effect of Medical Nutrition Therapy on metabolic risks
patients
Tzu-Ling CHEN 1, Hsiao-Lien CHEN2*, Yi-Jen WU 1,
Yu-Ying CHANG 1, Te-Shu WU1. 1Department of Dietician, Lo-Hsu
Medical Foundation, Lotung Poh-Ai Hospital, 2Division of
Endocrinology and Metabolism, Department of Internal Medicine,
Lo-Hsu Medical Foundation, Lotung Poh-Ai Hospital, Taiwan
Objective: Metabolic syndrome is a group of risk factors for
cardiovascular disease and other health problems, such as
diabetes and stroke. The aim of study is evaluate the effect of
Medical Nutrition Therapy (MNT) in metabolic risks patients.
Methods: This study recruited sixty-eight metabolic risks
patients who regular follow-up in outpatient service and
received 2 times of MNT within 11 months. Body weight,
waist circumference, fasting glucose, lipid profile were
assessed. We analyzed the body position and fasting glucose
and lipid profile through before and after intervention.
Results: The results showed the participants of men and
women were 25% and 75% and the mean age was 57.3 ± 9.98 yr
and 57.9 ± 9.35 yr respectively. Regular exercise more than 30
minutes and over five times a week was twenty-two people
(33%), three to five times a week was twelve people (18%).
After MNT intervention, the women group diastolic blood
pressure (form 81.91 ± 3.24 mmHg decreased to 75.11 ± 5.01
mmHg), fasting glucose (form108.96 ± 9.03 mg/dL decreased to
103.06 ± 11.68 mg/dL), cholesterol (form 227.84 ± 24.89 mg/dL
decreased to 194.75 ± 12.97 mg/dL), triglyceride (form 225.12 ±
120.36 mg/dL decreased to 145.07 ± 78 mg/dL),low- density
lipoprotein (form 39.18 ± 11.14 mg/dL decreased to 53.8 ± 9.26
mg/dL), and high- density lipoprotein (form 39.18 ± 11.14 mg/
dL increased to 53.8 ± 9.26 mg/dL) were significant (p < 0.05).
Conclusion: To conclusion, the MNT intervention could
improve the fasting glucose, diastolic blood pressure and
lipid profile in women group in our study patients.
PA-35
Matsuda index and clinical indicators of insulin resistance in
obese children and adolescents. Is there a correlation?
Eirini DIKAIAKOU1, Elpis-Athina VLACHOPAPADOPOULOU1,
Ioannis PANAGIOTOPOULOS1*, Ioanna PATINIOTI1,
Elli ANAGNOSTOU1, Foteini-Eleni KARACHALIOU1,
Eirini KALOUMENOU1, Aspasia FOTINOU2,
Stefanos MICHALACOS1. 1Dept. of Endocrinology-Growth and
Development, Children’s Hospital P. & A. Kyriakou,
2Biochemistry Dept.-Hormones Laboratory, Children’s Hospital
P. & A. Kyriakou, Greece
Background: Obesity-related insulin resistance is present in
obese children and Matsuda index is a method proposed to
evaluate insulin resistance, using data obtained from the oral
glucose tolerance test (OGTT). Early detection of children who
are at risk is important.
Objective and hypotheses: To evaluate the prevalence of
insulin resistance, as calculated by the Matsuda index, in
children with family history of obesity and/or Type II diabetes,
acanthosis nigricans and increased waist circumference and
to investigate whether they could be used as selectionmarkers
for patients to undergo OGTT. Moreover, to estimate the
correlation of insulin resistance with the coexistence of
metabolic syndrome.
Methods:Data from 95 overweight and obese children (47 boys
and 48 girls) with mean age 10.7 ± 2.2 years were analyzed.
Student’s t-tests were used for the comparison of means and
Pearson correlation coefficients were used to explore the
association of two continuous variables.
Results: Insulin resistance was found in 39.1% of the children,
while the mean MATSUDA index was 3.4 (SD = 1.9). Also, the
Mean Area Under the Curve (AUC) for glucose was 14211.3
(SD = 2016.5) and the mean AUC for insulin was 13484.2
(SD = 11985.3). A negative correlation of Matsuda index with
TSH (r = −0.33, p = 0.003), total cholesterol (r = −0.25, p = 0.030),
triglycerides (r =−0.44, p < 0.001) and LDL levels (r = −0.34,
p = 0.005), as well as with HOMA index (r =−0.55, p < 0,001)
was found. Moreover, the mean Matsuda index was 2.64 in
cases with acanthosis nigricans (p = 0.007). Additionally,
Matsuda index was significantly correlated with waist cir-
cumference (r = −0.40, p = 0.006). Furthermore, Matsuda index
was lower in those with metabolic syndrome and in puberty.
There was no sex difference regarding insulin resistance,
while it was greater in puberty. AUC for glucose was not
different according to the existence of metabolic syndrome
and acanthosis nigricans, in contrast with AUC for insulin
that was significantly greater in cases with acanthosis
nigricans (p = 0.007) or metabolic syndrome (p = 0.006). Waist
circumference was also predictive for AUC for insulin (r = 0.30,
p = 0.044).
Conclusion: The clinical indicators of family history of obe-
sity and diabetes, the presence of acanthosis nigricans and
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S75