Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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has not been determined. Therefore, we analyzed plasma
ANGPTL6 levels and other biochemical markers in patients
with T2DM.
A total of 108 Korean patients with T2DM were enrolled.
Subjects with known cardiovascular diseases, chronic kidney
disease, or active infection were excluded. Plasma ANGPTL6
was quantified. We assessed vascular health status by
measuring carotid intima-media thickness (IMT).
Plasma ANGPTL6 correlated positively with C-reactive protein
(CRP; r = 0.31, P < 0.01) and resistin (r = 0.28, P < 0.05), and
negatively with high-density lipoprotein (HDL) cholesterol
(r = −0.24, P < 0.05). However, ANGPTL6 did not correlate with
carotid IMT, adiponectin, or leptin. A multiple regression
analysis showed that CRP and HDL cholesterol remained
independently associated with ANGPTL6 after adjustment for
age, gender, body mass index, and resistin.
Circulating ANGPTL6 concentrations are positively associated
with inflammatory markers, and negatively with HDL choles-
terol in subjects with T2DM. Further studies will be needed to
explore the physiologic functions of ANGPTL6 in T2DM.
PJ-31
Association of serum uric acid concentration and
microvascular complications in Taiwanese patients with type
2 diabetes mellitus
Wei-Hao HSU 1,2, Pi-Jung HSIAO1,6 , Mei-Yueh LEE1,2,6,
Ching-Chao LIANG 5, Pi-Chen LIN1, Szu-Chia CHEN2,4,6,
Kun-Der LIN1,3 , Shyi-Jang SHIN1,6,7*. 1Division of Endocrinology
and Metabolism, Department of Internal Medicine, Kaohsiung
Medical University Hospital, 2 Department of Internal Medicine,
Kaohsiung Municipal Hsiao-Kang Hospital, 3Department of Internal
Medicine, Kaohsiung Municipal Ta-Tung Hospital, 4Division of
Nephrology, Department of Internal Medicine, Kaohsiung Medical
University Hospital, Kaohsiung Medical University, 5Department of
Laboratory Technology, Kaohsiung Municipal Ci Jin Hospital,
6 Graduate Institute of Clinical Medicine, College of Medicine,
Kaohsiung Medical University, 7Center for Lipid and Glycomedicine
Research, Kaohsiung Medical University, Kaohsiung, Taiwan
Patients with type 2 diabetes mellitus (DM) may have chronic
microvascular complications such as diabetic retinopathy
(DR) and diabetic nephropathy (DN) in their life. In clinical
studies, serum uric acid concentration was found to be
associated with DR and DN. The goal of this study is to
evaluate the relationship between the increase of serum uric
acid level and the severity of microvascular complications in
Taiwanese patients with type 2 DM. 385 patients with type 2
DMwere enrolled for obtaining serumuric acid level, the status
of DR severity, and the status of albuminuria severity by
calculating urinary albumin-to-creatinine ratio (UACR). In
multivariate logistic regression analysis, high uric acid was
the risk factor of albuminuria (OR, 1.227; 95% CI = 1.015 –1.482;
p = 0.034) and DR (OR, 1.264; 95% CI = 1.084–1.473; p = 0.003). We
also demonstrated that there was a higher concentration of
serum uric acid in the more severe form of albuminuria and
DR. In conclusion, increased serum uric acid level significantly
correlated with the severity of microvascular complications in
Taiwanese patients with type 2 DM.
PJ-32
A reduced risk of diabetes with aripiprazole exposure in
schizophrenia patients: A population-based retrospective
cohort study
Chun-Hung CHANG 1, Shaw-Ji CHEN2, Chieh-Yu LIU 3*.
1 Department of Psychiatry, China Medical University Hospital,
Taichung, 2Department of Psychiatry, Mackay Memorial Hospital
Taitung Branch, Taitung, 3Biostatistical Consulting Lab, Institute of
Nursing-Midwifery, National Taipei University of Nursing and
Health Sciences, Taipei, Taiwan
Objective: Aripiprazole exhibits protective effects for meta-
bolic syndromes, but the association between aripiprazole
use and the subsequent risk of diabetes in schizophrenia
patients is unclear. This population-based study is aimed to
assess the incidence and risk of diabetes among schizophrenia
patients who received aripiprazole treatment.
Methods: Using a nationwide database, the Taiwan National
Health Insurance Research Database, subjects who had first
been diagnosed with schizophrenia between 2002 and 2013
were identified. The schizophrenia patients receiving aripi-
prazole were designated as the aripiprazole group. A 1:1 ratio
was used to select age-, gender-, and index-year -matched
control without aripiprazole use. Patients who had diabetes
before enrollment were excluded. The 2 cohorts were observed
until December 31, 2013. The primary endpoint was occur-
rence of diabetes.
Results: Among 15,974 newly diagnosed schizophrenia
patients, we identified 3,462 patients with aripiprazole use,
and 3,462 matched patients without aripiprazole use between
January 2002 and December 2013. Of the 6,924 patients, 283
(4.09%) suffered from diabetes during a mean follow-up period
of 4.39 years, including 119 (3.44%) from the aripiprazole cohort
and 164 (4.73%) from the control group. In schizophrenia
patients, the Cox multivariate proportional hazards analysis
showed that the risk decreased with aripiprazole use 0.5884
(95% confidence interval (CI), 0.4970 to 0.6966; p < 0.0001).
Conclusions: Aripiprazole use was associated with a reduced
risk of diabetes among schizophrenia patients.
PJ-34
The synergistic effect of serum albumin and globulin on the
metabolic syndrome
Ji Eun JUN1, Seung-Eun LEE1 , You-Bin LEE1, Sang-Man JIN1,
Moon-kyu LEE1, Kyu Yeon HUR1, Jae Hyeon KIM 1*. 1Division of
Endocrinology and Metabolism, Department of Medicine, Samsung
Medical Center, Sungkyunkwan University School of Medicine, Korea
Serum albumin and globulin have been used as biochemical
parameters indicating different metabolic status. The aim of
this study is to clarify the association between serum albumin
and/or globulin and the presence of metabolic syndrome
(MetS).
A total of 24,185 adults aged ≥ 18 years underwent compre-
hensivemedical health check-ups annually over 7-year period.
Among them, 19,208 subjects were finally enrolled in the
research. Multivariate logistic regression analysis was used to
assess the risk of MetS according to the quartile of baseline
level of serum albumin and globulin, also as continuous
variables per 1 standard deviation (SD).
In a multivariate model adjusting for all possible metabolic
risk factors, the highest quartile of serum albumin (OR 1.21,
95% Confidence Interval [CI] 1.04–1.41; p for trend = 0.015) and
globulin (OR 1.47, 95% CI 1.27– 1.70; p for trend <0.001) were
associated with an enhanced risk of MetS compared with
lowest tertile. However, serum albumin as continuous vari-
ables per 1 SD lost its significance on the risk of MetS in a fully
adjusted model, while serum globulin were still significant. In
the conditional logistic model adjusting for all covariates and
dividing subjects into 4 groups (low albumin + low globulin;
high albumin + low globulin; low albumin + high globulin; high
albumin + high globulin) according to the median values of
albumin and globulin levels, the synergistic effect of albumin
and globulin on MetS was found when both of themwere high
(OR 1.42, 95% CI 1.22–1.47; p < 0.001), compared with thosewith
low albumin and low globulin.
High serum albumin and globulin were independently asso-
ciated with the presence of MetS. The synergistic effect of
both high albumin and globulin on MetS was greater than
either one alone.
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S202