Diabetes Research and Clinical Practice - Volume 120 - Supplement 1

<7.8 mmol/L; (3) IGT: 2-h PG of 7.8

–

11.0 mmol/L and FPG

<7.0 mmol/L. Categories of serum uric acid level were defined

by gender-specific quartiles.

Results:

There were significant differences in age, gender,

education level, body mass index, waist circumstances,

systolic and diastolic blood pressure, FPG,2-h PG, uric acid,

lipid profiles, and the prevalence of hyperuricemia (upper

quartile), hypertension, hypertriglyceridemia, low HDL-C,

family history of diabetes, cigarette smoking and alcohol

drinking among three groups. Based on multinomial regres-

sion analysis, highest quartile of uric acid level was positively

associated with IGT (OR = 1.39, 95%CI: 1.12

–

1.74), but not IFG

(OR = 1.46,95%CI: 0.97

–

2.18), after adjusting for age, gender,

body mass index, hypertriglyceridemia, low HDL-C, education

level, family history of diabetes, cigarette smoking, alcohol

drinking and regular exercise.

Conclusions:

Increased serum uric acid may increase a higher

risk of IGT but not IFG.

PJ-20

The association of gastric Helicobacter pylori infection,

diabetes and pre-diabetes in a Taiwanese population

Gi-Hua YANG

, Jin-Shang WU

, Yi-Ching YANG

Ying-Hsiang HUANG

, Feng-Hwa LU

, Chin-Jen CHANG

Department of Family Medicine, National Cheng Kung University

Hospital, Tainan, Taiwan

Aims:

Emerging literatures revealed Helicobacter pylori (H.

pylori) infection playing a role in extra-gastric diseases. Some

of previous studies demonstrated higher prevalence of

H. pylori infection in diabetic patients, but others revealed no

difference. Association between glycated hemoglobin levels

and H. pylori immunoglobulin G antibodies was also reported.

However, there was little evidence about relation between

gastric H. pylori infection and pre-diabetes.

Methods:

This cross-section study enrolled 19,694 participants

with health examination in the National Cheng Kung

University Hospital from July 1997 to October 2007. Biopsy

was performed in 1,866 subjects out of 11,653 subjects who

underwent esophagogastroduodenoscopy (EGD). Finally 1,285

subjects were available for analysis after exclusion criteria

consisting of age <18 years old, biopsy of esophagus or

duodenum, endoscopic diagnosis of cancer proven by histo-

pathological examination, prior upper gastrointestinal tract

surgery, prior Helicobacter eradication therapy, use of non-

steroid anti-inflammatory drugs and incomplete data. H.

pylori infection was defined as H. pylori present in samples

of gastric biopsy by EGD. Diabetesmellitus (DM) was defined as

fasting plasma glucose (FPG)

≧

126 mg/dL, 2 hour-post load

glucose (2 h-PG)

≧

200 mg/dL, or a positive DM history. Pre-

diabetes was defined as FPG of 101

–

125 mg/dL or 2 h-PG of 141

–

199 mg/dL without DM.

Results:

DM was diagnosed in 238 (18.5%) and pre-diabetes in

318 (24.7%) of the 1,285 subjects. There were significant

differences in age, gender, education level and the prevalence

of hypertension, prehypertension, H. pylori infection, hepa-

titis C infection, hypertriglyceridemia, low HDL-C, C-reactive

protein >8.0 mg/L and family history of DM among subjects

with normal blood glucose, pre-diabetes and DM. Multivariate

analysis showed age, obesity, family history of DM, hyperten-

sion and hypertriglyceridemia were significantly related to

both pre-diabetes and DM H. pylori infection were positively

associated with DM (odds ratio 1.42, 95% confidence interval

1.01

–

2.01), but not pre-diabetes (odds ratio 1.02,95% confidence

interval 0.77

–

1.36), in addition to male gender, education level,

prehypertension and low HDL-C.

Conclusions:

Gastric H. pylori infection may increase the risk

of DM, but not pre-diabetes. In clinical practice, we recom-

mend to monitor plasma glucose level in subjects with gastric

H. pylori infection.

PJ-21

Gait speed as a predictor of all-cause mortality in community-

dwelling elderly people in Japan: The Mima cohort study

Shinji FUJIWARA

1,2

, Kazuhiko KOTANI

2,3

, Kokoro TSUZAKI

Naoki SAKANE

Mima City National Health Insurance Koyadaira

Clinic,

Division of Preventive Medicine, Clinical Research Institute,

National Hospital Organization Kyoto Medical Center,

Division of

Community and Family Medicine, Center for Community Medicine,

Jichi Medical University, Japan

Background:

Japan

’

s aging rate is currently the highest in the

world. The number of peoplewith diabetes is increasing due to

urbanization, aging, and increasing prevalence of obesity and

physical inactivity. The aim of the Special Health Check-up

(SHC) and Guidance System initiated in 2008, targeting people

–

74 years of age, was to detect those with Metabolic

Syndrome and to offer lifestyle modification services that

lead to the reduction of type 2 diabetes and diabetes-related

death. The Mima Cohort Study was looking for its own

important themes to focus on for their public health activities.

Objectives:

To identify factors related with death among the

general population in Mima City.

Method:

3,752 community-dwelling people (mean age 63.5 +/

−

8.2 (SD) years old, 1,623 male and 2,129 female) in Mima City

who took SHC from 2009 to 2014 were followed up for a mean

period of 2.4 years (9,059 person-years). Association between

deaths and factors tested by SHC was analysed.

Results:

104 subjects (72 male and 32 female) died during the

study period, including 42 from cancers, 10 from cardiac

events, 8 from stroke, and 44 from other causes. For males,

multiple Cox proportional hazards regressionmodels adjusted

for age showed all-cause death was positively associated with

estimated glomerular filtration rate (eGFR) less than 45 mL/

min/1.73 m

[hazard ratio (HR) 4.6 (95% confidence interval

2.1

–

10.1)], history of stroke [HR 3.8 (1.7

–

8.1)], high-density

lipoprotein cholesterol (HDL-C) levels less than 40 mg/dL [HR

3.0 (1.7

–

5.5)] and AST more than 40 [HR 2.5 (1.2

–

5.4)], and

negatively associated with self-reported fast gait speed [HR

0.45 (0.26

–

0.79)]. In subgroup analysis, the model showed the

association between all-cause death and self-reported fast gait

speed was seen only in the group aged 65

–

74 [HR 0.33 (0.16

–

0.67)]. For females, the model didn

’

t show any association

between death and these factors. However, univariable Cox

proportional hazards regression models showed a positive

association between all-cause death and being aged 65 and

over [HR 7.3 (2.6

–

21.0)], proteinuria [HR 5.1 (1.9

–

13.1)], eGFR less

than 45 mL/min/1.73 m

[HR 3.8 (1.1

–

13.0)], and taking medi-

cation for diabetes [HR 3.8 (1.4

–

9.9)].

Conclusion:

Several factors relating to kidney disease, HDL-C,

medical history, and gait speed were associated with deaths in

men over a short period of time. These factors should be

themes for public health activities in Mima City. Beyond trying

to improve laboratory findings for preventing early deaths,

walking fast may also be important, especially for elderly

people.

PJ-22

Increased risk of heart failure in diabetic patients of Taiwan:

Age- and sex-stratified population-based study

Hua Fen CHEN

1,2

*, Chung Yi LI

Department of Endocrinology,

Far Eastern Memorial Hospital,

School of Medicine, Fujen Catholic

University, New Taipei City,

Department of Public Health, College of

Medicine, National Cheng Kung University, Tainan City, Taiwan

Background and aims:

Diabetes is regarded as a coronary heart

disease (CHD) equivalent, but the risk of heart failure (HF)

between diabetic patients and non-diabetic subjects has

scarcely been compared before. This study used a nationally

representative cohort selected fromNational Health Insurance

to compare the relative hazard of heart failure in diabetic

patients and non-diabetic subjects.

Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65

–

S211

S199