Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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4.34 uIU/mL. Postprandial hyperinsulinemia related hypo-
glycemia was defined because of absence of pancreatic
lesion detected by triple-phase spiral computed tomography.
The hypoglycemia was well corrected by cortisone acetate
75 mg/day and dietary adjustments to keep normal blood
glucose level ranged from preprandial 80 –100 mg/dL to post-
prandial 83 – 120 mg/dL.
Secondary diabetes was frequently induced by immunosup-
pression therapy, especially tacrolimus. But hypoglycemia in
case of liver transplantation always hints the poor prognosis
for the transplanted liver. However, our case was well handled
by the steroid treatment and dietary adjustments even
complicated by hypoglycemia. Hypoglycemia after bariatric
surgery is reported rare (<1%) but often arises within 3 years
after operation. The dumping effect may be caused by
the enhanced GLP-1 effect and pancreatic nesidioblatosis.
Therefore, the exaggerated GLP-1 secretion and improved
insulin sensitivity may rationally contribute to the hypogly-
cemia in our patient.
PI-42
The effects of aerobic exercise training on chemerin, apelin,
and visfatin in obese young males
Ji Sun NAM 1*, Sang Bae LEE1, Ji Hong YOU1, Min Young LEE1,
Eun Jung KIM 1, Min Jin KIM 1, Min Kyung KIM1, Yu-Sik KIM1,
Shinae KANG 1, Jong Suk PARK 1, Chul Woo AHN1,
Kyung Rae KIM 1. 1 Gangnam Severance Hospital, Korea
Objective: Recent evidence suggests that adipose tissue is
not only a passive reservoir for excess energy but also an
active endocrine organ which secretes more than 600 bio-
activemolecules, namely, adipokines. Among newly identified
adipokines, visfatin, chemerin and apelin are reported to be
associated with obesity and type 2 diabetes mellitus. We
investigated the exercise-induced changes in novel adipokines
related to obesity and insulin resistance and their correlations
with the changes in body fat composition and metabolic
parameters after exercise.
Study design and methods: Forty young obese Korean males
were randomly assigned to control and exercise group, who
received 8-week supervised exercise training program. Body
fat compositions and various metabolic parameters and
adipokines were assessed before and after exercise.
Results: Significant reductions of body weight, total and
truncal fat, and waist circumference and significant improve-
ment in insulin resistance, systolic blood pressure, and LDL-
cholesterol were observed in Exercise group (all p < 0.001).
Serum visfatin, chemerin, and apelin levels were decreased
after exercise (p < 0.005). Changes in body fat composition
were significantly associated with changes in adipokines, and
multiple linear regression analyses showed theses adipokines
to be independent predictors of changes in insulin resistance,
and in case of chemerin, fasting glucose as well.
Conclusions: Aerobic exercise led to improvements in insulin
resistance and glucose homeostasis independent of changes
in body composition and conventional adipokines, and
visfatin, chemerin and apelin seem to be involved in the
etiology of obesity and insulin resistance.
Using Big Data for Research and Care
in Diabetes
PJ-01
Efficacy of exercise on HbA1c, lipid profiles and BMI changes in
diabetic patients participating shared care programs
Sin Yu HSU 1*, Ming Chun KUO 1. 1Division of Endocrinology and
Metabolism, Kaohsiung Chang Gung Memorial Hospital and Chang
Gung University College of Medicine, Kaohsiung, Taiwan
Aim/introduction: Exercise for diabetics is very economic,
benefits for their well beings, and can effectively lower blood
sugar and blood lipid levels. We analyze the efficacy of type,
duration, and frequency of exercise in patients with diabetes
mellitus joining our diabetes health care improvement pro-
grams less than two years on the changes of A1C, bl.
Method/material: From January 2012 to June 2014, a total of 227
diabetic subjects entering our “ diabetes health care improve-
ment programs” for more than 2 years were retrieved for
analysis. We excluded those were lost to follow-up, unfinished
at any stage of the programs, and did not do exercise. Exercise
groups are defined as exercising once a week, and for at least
10 minutes a time. We recorded the types, duration, and
frequency of their exercise. The causes were collected in those
with no exercise. We compared the changes in A1c, blood lipid
profiles, and BMI between two groups. Statistical methods
were Bivariate T-test and for Independent-Samples. ood lipid
profiles, and BMI.
Results: About 80.7% had awalk in exercise group; the portions
of exercise group had a duration more than 30 minutes a time
is about 54%; 55.3% of exercise group had a frequency of 7 times
a week.
Causes of non-exercise group were no time (40.9%), especially
in the hot weather (accounting for 3%). The lipid profile
changes in non-exercise group versus exercise group were
0.032 ± 0.232 mg/dL and −0.045 ± 0.316 mg/dL in total choles-
tereols (p = 0.04); −0.095 ± 0.623 mg/dL and −0.414 ± 1.203 mg/
dL in triglycerides (p = 0.01); and 0.076 ± 0.35 mg/dL and −0.047
± 0.463 mg/dL in LDL (p = 0.31).
The aging subjects had more exercise frequencies (p = 0.03).
The more stronger strength of the exercise, the more time the
subjects did the exercise (p < 0.001), which also correlated with
the reduction of the levels of cholesterol (p = 0.009), and LDL
(p = 0.03).
Conclusions: Our study suggests exercise helped reduce blood
lipid profiles, but did not significantly improve the A1C, BMI
and HDL levels. It may be associated with oral hypoglycemic
agents and insulin use. Most people have no time to exercise,
andmay be related towork and no family support. Hot weather
can also affect the motivation for exercise.
PJ-02
Mortality and causes of death from 2002 to 2013 in a national
sample of diabetic patients in Korea
Yu Mi KANG1, Ye Ji KIM2, Joong-Yeol PARK 1, Woo Je LEE1 ,
Chang Hee JUNG1*. 1Department of Internal Medicine, Asan
Medical Center, University of Ulsan College of Medicine,2 Department
of Biostatistics, Asan Medical Center, University of Ulsan College of
Medicine, Seoul, Korea
Objective: We investigated the mortality rate (MR), causes of
death and standardized mortality ratio (SMR) in Korean
diabetic populations using data from the Korean National
Health Insurance Service (NHIS) National Sample Cohort 2002
to 2013.
Research design and methods: From 1,000,000 NHIS National
Sample Cohort, we identified 29,807 diabetic subjects (aged
more than 30 years) from 2002 to 2004. Individuals having
diabetes were defined if anti-diabetic drugs were prescribed
with the presence of ICD-10 codes (E11 to E14) as diagnosis.
Specific causes of death were classified into the following
categories according to ICD-10 codes: diabetes, malignant
neoplasm, disease of the circulatory system, and other causes.
Among deaths due to the circulatory system, deaths due to
ischemic heart diseases and cerebrovascular diseases were
further analyzed.
Results: A total of 7,103 (23.8%) deaths were recorded. MR
tended to increase with age. The MR ratio for men versus
women was highest in their 40s to 50s. The overall SMR was
2.32 and SMRs attenuated in the elderly. Causes of death
ascribed to diabetes, malignant neoplasm; ischemic heart
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S194