Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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PJ-15
LDL-C/APOB and HDL-C/APOA-1 ratios predict
incident chronic kidney disease in a large apparently
healthy cohort
Ji Cheol BAE 1, Sam KWON1, Jae Hyeon KIM2*. 1Division of
Endocrinology and Metabolism, Department of Medicine, Samsung
hangwon Hospital, Sungkyunkwan University School of Medicine,
2 Division of Endocrinology and Metabolism, Department of Medicine,
Samsung Medical Center, Sungkyunkwan University School of
Medicine, Korea
Introduction: The objective of this study was to evaluate the
ability of lipid variables to predict the development of chronic
kidney disease (CKD). We investigated the longitudinal asso-
ciation between lipid profiles and incident CKD in a large
apparently healthy cohort.
Materials and methods: A retrospective longitudinal analysis
of 10,288 subjects who had participated in comprehensive
health check-ups at least four times over a 7-year period was
conducted. The risk of incident CKD associated with lipid
variables was analyzed using adjusted hazard ratio (HR) for
CKD per 1 standard deviation (SD) increase in lipid level. The
development of CKD was defined as estimated glomerular
filtration rate <60 mL/min/1.73 m 2.
Results: Over a mean follow-up of 56.5 ± 14.3 months, 356
(3.5%) subjects developed CKD. The multivariate adjusted
HRs for incident CKD per 1 SD increase in baseline lipid
level were 1.29 (95% confidence interval [CI], 1.17–1.41) for
triglycerides (TG), 0.77 (0.68 –0.88) for high-density lipoprotein
cholesterol (HDL-C), 1.22 (1.12 –1.32) for the TG/HDL-C ratio,
0.82 (0.73 to 0.92) for the low-density lipoprotein cholesterol/
apolipoprotein B (LDL-C/apoB) ratio, and 0.74 (0.66 –0.83) for the
HDL-C/apoA-1 ratio. No longitudinal association was found
between incident CKD and baseline total cholesterol, LDL-C,
non-HDL-C, the LDL-C/HDL-C ratio, apoB, apoA-I, or the apoB/
apoA-I ratio.
Conclusion: The LDL-C/apoB and HDL-C/apoA-1 ratios as well
as TG and HDL-C concentrations independently predicted an
increased risk for developing CKD. Our findings suggest that
particle size rather than the number of HDLs and LDLs
contribute to the development of CKD.
PJ-17
The function of betatrophin in the prediction of nonalcoholic
fatty liver and its progress
Xiaojuan SHAO 1*, Wen HU1, Weinan YU1. 1Huai’an Hospital
affiliated to Xuzhou Major Medical, China
Objective: To study the function of betatrophin in the
prediction of nonalcoholic fatty liver (NAFLD) and its progress.
Methods: A total of 249 subjects based on ultrasonic quanti-
tative determination of fat content (LFC) were divided
into three groups, Control, (LFC < 9.15%, n = 84), low liver fat
content, (9.15% ≤ LFC≤ 20%, n = 82), high liver fat content,
(LFC > 20%, n = 83). Anthropometric and biochemical examina-
tions were performed. Betatrophin and clinical factors were
measured by Elisa Kit.
Results: Serum Betatrophin were showed significant differ-
ences in the three groups (p < 0.01). Adjusted by gender, age,
the Betatrophin levels were positively correlated with LFC
(r = 0.231, p < 0.01). Multivariate linear regression analysis
showed that the serum Betatrophin levels were independent
factors affecting the LFC (P < 0.05).
Conclusion: Betatrophin is an independent risk factor for
NAFLD and its progress. Checking serum Betatrophin will help
clinical doctors to identify NAFLD earlier and improve the
prognosis.
PJ-18
The association between hyperglycomia and hearing
impairment in a Taiwanese adult population
Ney-Min WU1, Jin-Shang WU1, Yi-Ching YANG1,
Chin-Song CHANG1, Feng-Hwa LU 1, Chin-Jen CHANG1*.
1Department of Family Medicine, National Cheng Kung University
Hospital, Tainan, Taiwan
Aim: There were some studies to explore the relationship
between hyperglycemia and hearing impairment, and the
results were inconsistent. The aim of this study was to
investigate the association between different glycemic status
and hearing impairment in a Taiwanese population.
Methods: From April 2002 to August 2009, participants
undergoing a comprehensive health check-up were evaluated
by audiometric testing. Hearing impairment were assessed
from the pure tone average of thresholds over low frequencies
(500, 1,000, 2,000 Hz) and high frequencies (3,000, 4,000,
6,000 Hz), and defined for mild or greater severity (pure tone
average >25 decibels hearing level). All subjects were divided
into 3 groups, including normal glucose tolerance (NGT), pre-
diabetes (pre-DM), and diabetes mellitus (DM). A multiple
logisticmodel was used for analyzing the relationship between
hearing impairment and different glycemic status, with
adjustment for other variables.
Results: Of 4,995 recruited participants, 239 subjects (4.8%) had
low frequency hearing impairment, while 460 subjects (9.2%)
had high frequency hearing impairment. The prevalence of
low frequency hearing impairment was 3.9%, 5.1%, and 9.7% in
NGT, pre-DM, and DM group, and those of high frequency
hearing impairment was 6.8%, 11.8%, and 19.7%, respectively,
Multivariate analysis revealed a positive association between
diabetes and high frequency hearing impairment (odds ratio
[OR] = 1.75,95% confidence interval [CI] = 1.19–2.57, p = 0.004),
but not between pre-diabetes and high frequency hearing
impairment (OR = 1.13,95% CI = 0.83– 1.53, p = 0.45) after adjust-
ing for other variables. In addition, older age (age ≥ 40–<60,
OR = 4.61, 95%CI = 2.84– 7.49, P < 0.001; age ≥ 60 years, OR =
17.70, 95% ci = 9.74–32.18, p < 0.001), body mass index ≥25 vs.
<23 (OR = 1.64, 95% CI = 1.10–2.44, p = 0.01), and smoking (OR =
1.52, 95% CI = 1.04–2.22, p = 0.03) were the associated factors of
high frequency hearing impairment.
Conclusions: Diabetes mellitus, but not pre-diabetes, is an
important associated factor of high frequency hearing impair-
ment, in addition to older age, obesity, and smoking.
PJ-19
The association of serum uric acid and pre-diabetes in a
Taiwanese population
Man-Chun WU1, Yi-Ching YANG 1, Jin-Shang WU1,
Ru-Hsueh WANG1, Feng-Hwa LU1, Chin-Jen CHANG1*.
1Department of Family Medicine, National Cheng Kung University
Hospital, Tainan, Taiwan
Background/aims: Individuals with diabetesmellitus (DM) and
pre-DM, including impaired fasting glucose (IFG) and glucose
tolerance (IGT), had a high risk of cardiovascular and all- cause
mortality. Hyperuricemia has been reported to be a risk factor
for coronary heart disease and often co-present with obesity,
hypertension and hyperlipidaemia. Hyperuricemia is also an
established risk factor for DM but not pre-DM. Therefore, the
aim of this study was to investigate the relationship between
serum uric acid and pre-diabetes in a Taiwanese population.
Methods: A total of 7,469 adults were recruited for the final
analysis after exclusion of individuals with a history of DM,
chronic kidney disease, and those with newly-diagnosed DM,
and current usage of medication for DM, hypertension,
hyperlipidemia, hyperuricemia, heart disease, and cerebral
vascular disease. Subjects were classified into three groups
according to their glycemic status: (1) normal glucose toler-
ance: Fasting plasma glucose (FPG) < 5.6 mmol/L and 2-h PG <
7.8 mmol/L; (2) isolated IFG: FPG of 5.6–6.9 ol/L and 2-h PG
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S198