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poorly understood. Here, we investigated the association
between early menarche and risk factors for developing CVD
during adulthood using a nationwide population database.
In total, 12,336 women (weighted n = 17,483,406; weighted age,
45.7 years) who participated in the Korean National Health and
Nutrition Examination Survey 2010–2013 were included in this
study. Participants were scored using the National Cholesterol
Education Program Adult Treatment Panel III criteria for
metabolic syndrome. Risk of CVD was estimated using the
10-year Framingham Coronary Heart Disease Risk Point Scale
(10-yr FRS).
Early menarche ( ≤11 years) was reported in 5.2% (weighted
n = 917,493) of subjects. The weighted prevalences of meta-
bolic syndrome and ≥20% 10-yr FRS were 23.6% (95% CI, 22.7–
24.6) and 7.7% (7.1 –8.3), respectively. Women with early
menarche reported a significantly higher body mass index
and waist circumference, along with a higher prevalence of
hypertension, diabetes, and metabolic syndrome compared
with those with later menarche ( ≥13 years). Furthermore, the
prevalence of women with a ≥ 10% or ≥20% 10-yr FRS was
higher in those with early menarche compared with other
groups after adjusting for age, smoking, education level,
and menstruation. Logistic regression analyses controlling
for these and other confounding factors revealed odds ratios
of 2.29 (95% CI = 1.25–4.19) and 1.78 (0.96–3.30) for ≥10%
and ≥20% 10-yr FRS in women with early menarche, respect-
ively, compared with those in the latest menarche group ( ≥ 17
years).
Taken together, this nationwide study revealed women with
early menarche are at increased risks of metabolic syndrome
and CVD. Early menarche may therefore represent an import-
ant marker for early preventive interventions.
PJ-27
Association of complete blood cell counts with metabolic
syndrome in an elderly population
Peng-Fei LI1, Jin-Shuen CHEN1, Jin-Biou CHANG1, Dee PEI1,
Chang-Hsun HSIEH1, Yen-Lin CHEN 1*. 1Division of Endocrinology
and Metabolism, Department of Internal Medicine, Tri-Service
General Hospital, National Defense Medical Center, Taipei, Taiwan
Objective: The role of metabolic syndrome (MetS) in predicting
cardiovascular diseases and diabetes has been repeatedly
confirmed in many large cohort studies. As a non-traditional
component, hematogram components are shown to be
significantly related to MetS in many different age groups.
However, little is known about the role of the hematogram
among the elderly.
Methods: We enrolled 18,907 subjects over the age of 65 years
who underwent regular health examinations. They were
divided into three groups according to their ages: young old
(YO: ≥65 and <74 years old), old old (OO: ≥75 and <84 years old),
and oldest old (ODO: ≥85 years old). The MetS components
were determined, and correlations between MetS and hema-
togram components were evaluated using Pearson and
multivariate linear regression analyses. Here, the hematogram
components were taken to be independent variables and were
evaluated separately against the dependent variable (MetS
components).
Results: While SBP and HDL-C became higher, most other MetS
and hematogram parameters became lower in men as they
aged. Fewer significant differences were noted among the
women. In the YO and OO groups for both genders, not
surprisingly the subjects with MetS had higher WBC and Hb.
Interestingly, none of the hematogram components were
different for subjects with or without MetS in the ODO group.
The results of the multiple regression show that most of the
relationships between hematogram and MetS components
disappeared in the ODO groups. The WBC levels were
mainly correlated with WC and TG. At the same time, Hb
was found to be associated with BP, FPG, and LDL-C. Compared
to WBC and Hb, PLT was least related to MetS, except in the
cases of LDL-C and TG. Among the MetS components, it is
interesting to note that BMI, LDL-C, and TG were consistently
related to all the hematogram components in YO and OOmen.
However, only TG had the same consistency among YO and OO
women.
Conclusions: This study’s three major findings are as follows:
1. WBC and Hb are indeed associated with MetS, even among
the YO and OO groups, regardless of gender; among the three
hematogram components, Hb had the strongest and PLT had
the weakest correlation with MetS; and TG is not the only
component that had relatively higher r values, but it is also
related to all hematogram components.
PJ-29
Plasma aldosterone concentration predicts the incidence of
diabetes mellitus
Tien-Jyun CHANG1, Hung-Yuan LI1*, Tse-Ya YU2,
Jung-Nan WEI3, Lee-Ming CHUANG1,4,5. 1Department of Internal
Medicine, National Taiwan University Hospital, Taipei, 2Health
Management Center, Far Eastern Memorial Hospital, New Taipei
City, 3Chia Nan University of Pharmacy and Science, Tainan,
4Graduate Institute of Clinical Medicine, Medical College, National
Taiwan University, 5Graduate Institute of Preventive Medicine,
National Taiwan University School of Public Health, Taipei, Taiwan
Objective: Genetic variation in aldosterone synthase is asso-
ciated with diabetes. Suppression of intestinal and urinary
glucose absorption by aldosterone through sodium-glucose
cotransporters may be the key mechanism. However, it
remains unknown if plasma aldosterone predicts the inci-
dence of diabetes in human. In this study, we investigated if
plasma aldosterone concentration is associated with the
incidence of diabetes in a community-based prospective
cohort without any medication for hypertension.
Research design and methods: We included 608 subjects
without diabetes at baseline and followed them for an
average of 4.01 years. Subjects who received medications for
hypertension at baseline or during follow-up were excluded.
Diabetes was diagnosed by results from an oral glucose
tolerance test and hemoglobin A1c, and if the subject was
taking medications for diabetes. Plasma aldosterone concen-
tration at baseline was measured with an ELISA kit.
Results: During follow-up, 42 subjects (6.91%) developed type 2
diabetes. Plasma aldosterone concentration was negatively
associated with body mass index (r = −0.0978, p = 0.0162), but
was not correlated with glycemic indices, HOMA2-%B, or
HOMA2-IR (all p > 0.05) at baseline. Plasma aldosterone con-
centration predicts the incidence of type 2 diabetes signifi-
cantly, after adjusting for age, family history of diabetes, body
mass index, HOMA2-%B, HOMA2-IR, and hemoglobin A1c
(HR = 0.83 for every 10 pg/mL increase in plasma aldosterone
concentration, 95%CI 0.692– 0.986, p = 0.034; HR = 0.31 for sub-
jects with plasma aldosterone concentration in the highest
tertile, 95%CI 0.14–0.71, p < 0.01).
Conclusions: Plasma aldosterone concentration predicts the
incidence of type 2 diabetes independently.
PJ-30
Angiopoietin-like protein 6 is associatedwith an inflammatory
marker and low HDL cholesterol in type 2 diabetes
Hyeong Kyu PARK1*, Mi Kyung KWAK1, Hye Jeong KIM1,
Dong Won BYUN1, Kyo-Il SUH1, Myung Hi YOO1.
1Soonchunhyang University Hospital, Korea
Angiopoietin-like protein (ANGPTL) 6, a novel hepatokine, is
known to modulate angiogenesis and metabolism. ANGPTL6
has been shown to be higher in metabolic syndrome than in
healthy individuals. Recent clinical data suggest a potential
role of ANGPTL6 in endothelial dysfunction. However, the
functional role of ANGPTL6 in type 2 diabetes mellitus (T2DM)
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S201