Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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lipoprotein cholesterol was lower among men with CAG repeat
≥ 23 than thosewith CAG repeat <23 (2.4 ± 0.7 vs 2.5 ± 0.7 mmol/
L, p = 0.051) at borderline significance. The group with CAG
repeat ≥23 had higher urine albumin-creatinine ratio (2.7
[IQR: 0.9,21.6] vs. 1.9 [IQR:0.7,11.5 mg/mmol, p = 0.046),
although mean GFR and frequencies of other baseline micro-
and macrovascular complications were similar to the other
group. Over mean follow-up time of 5.2 years, the incidence of
CVD, CKD and death per 1,000 person-year were 31.0 and 24.6
(p = 0.354), 188.0 and 140.6 (p = 0.022), and 14.2 and 14.0
(p = 0.964) in men with CAG repeat ≥23 and those with repeat
<23, respectively.
Men with longer CAG repeat length denoting diminished AR
sensitivity had similar cardio-metabolic control but higher
albuminuria than men with shorter CAG repeats. For compar-
able age and disease duration, men with longer CAG repeats
had higher incidence of CKD, whilst rates of CVD and death did
not differ.
PB-28
An investigation on the factors of diabetic patients’ cognition
of diabetic control indicators
Hiu-Fang WANG 1*, Chiao-Yun CHEN1, Ya-Yu TSENG1,
Sin-Huei WU 1, Hung-Ling SU 1, Pei-Shiuan SHEN1,
Chun-Chun YAU 1, Hsiang-Ju CHEN1. 1Diabetes Center, Changhua
Christian Hospital, Taiwan
Background: The ABCs of diabetes (A1c, Blood pressure,
Cholesterol) is promoted in international diabetes educa-
tion program to strengthen diabetes management of the
general public and medical professionals, reduce occurrence
of diabetic complications, and decrease mortality rate.
Objectives: This study aims to investigate how diabetic
patients understand diabetic control indicators and the
influential predictors of diabetic control indicators.
Methods: This survey was based on pruposive sampling.
The subjects were diabetic patients in a medical center in
central Taiwan from November 1, 2014 to August 31, 2015. A
self-designed questionnaire, verified in terms of reliability
(Cronbach’s α = 0.731) and validity (CVI = 0.94) was used.
Results: There were totally 1313 subjects, including 661 males
(50.3%) and 652 females (49.7%). For disease type, there were
144 type I patients (11.0%), 1166 type II patients (88.8%) and
2 other types patients (0.2%). Most of the subjects were
elementary school graduates. The mean age of the subjects
was 58.03 ± 17.85. The mean disease duration was 11.76 ± 8.13
years. The average glycated hemoglobin was 7.35 ± 1.34%. As
for the questionnaire response, 0.1% of the subjects were
totally correct, 27.4%were correct regarding blood sugar, 28.7%
were correct regarding blood pressure, and 0.7% were correct
regarding lipid. Significant differences were noticed in terms of
education level (college and unversity), disease duration (11 –15
and 16 –20 years), age (21–30) and disease type (type I diabetes)
(p < 0.001). Age, disease duration, disease type and education
level were found to be the predictors of diabetic control
indicators based on regression analysis.
Conclusion: In this research, less then 1% of the subjects
thoroughly understand blood sugar, blood pressue and lipid,
the key diabetic control indicators of diabetes. The findings
indicate the importance of diabetes health education of
diabetic patients.
PB-31
Green tea but not coffee consumption is inversely associated
withmetabolic syndrome; An epidemiological study in Korean
adults
EunHeui KIM 1, MinJin LEE1, Sung Su KIM1, Jong Ho KIM1,
Yun Kyung JEON1, Bo Hyun KIM1, In Joo KIM 1*, Yong Ki KIM2.
1 Department of Internal Medicine, Pusan National University
Hospital, Busan, 2Kim Yong Ki Internal Medicine Clinic, Busan, Korea
Background: Cumulative evidence suggests that intake of
caffeinated beverages, such as coffee and green tea, may
have beneficial effects onmetabolic syndrome (Mets). The aim
of this study was to evaluate whether or not consumption of
coffee or green tea was associated with the prevalence of Mets
in a Korean population.
Methods:We analyzed 15,568 Korean adults, aged 19–65 years,
using cross-sectional data from the The Sixth Korea National
Health and Nutrition Examination Survey (KNHANES VI-2,
2013–2015). Coffee consumption level was assessed based on
food frequency questionnaire and 24-h recall. Demographic
and lifestyle factors were assessed using self-administered
questionnaires. Data on metabolic biomarkers were obtained
from a health examination. Multivariate analyses were per-
formed to clarify the association between coffee or green tea
consumption and the components of metabolic syndrome.
Results: Among all components of metabolic syndrome, high
systolic blood pressure was inversely associated with the
frequency of green tea consumption (p = 0.005), after adjusting
for sex, age, body mass index, smoking status, drinking status.
And in female, HDL was associatedwith the frequency of green
tea consumption (p = 0.036). However, the consumption of
coffee was not significantly associated with the prevalence of
metabolic syndrome or its components.
Conclusions: Green tea but not coffee consumption was
inversely associated with metabolic syndrome.
PB-32
Anti-tissue transglutaminase autoantibodies and DQB1
genotypes in patients with type 1 diabetes
Yann-Jinn LEE1–3,5 *, Chi-Yu HUANG 1,4, We-Hsin TING1,4,
Yu-Ting HSIEH2, Chiung-Ling LIN 3, Thung-Shen LAI2,
Chon-In CHAN 1. 1MacKay Children’s Hospital, 2MacKay Medical
College, 3MacKay Memorial Hospital, 4MacKay Medicine, Nursing
and Management College, 5Taipei Medical University, Taiwan
Celiac disease is an immune disorder that affects the small
bowel and that is triggered by ingested gluten from barley, rye,
and wheat. It is characterized by small intestinal damage with
loss of absorptive villi and hyperplasia of the crypts, typically
leading to malabsorption. IgA and/or IgG antibodies to tissue
transglutaminase (tTG) are present in the sera of patients. The
prevalence of celiac disease is 3.3–10/1000 in Caucasians
whose food contains gluten. However celiac disease has been
rarely reported in Asian people.
Celiac disease is more frequent in Caucasian patients with
type 1 diabetes (T1D) with a prevalence of 1– 16%. We
hypothesized that celiac disease is also less frequent in
Asian patients with T1D. Therefore we investigated the tTG
Abs in patients with T1D.
Material and methods: The subjects were 354 T1D patients
consisting of 163 males and 191 females. Their mean (SD) age
at diagnosis was 8.0 (4.8), range 0.5–40.7 years, and disease
duration 11.0 (6.6), range 0.1–34.7 years. T1D was diagnosed on
the basis of clinical manifestations and laboratory evidence.
Patients had a HbA1c level of ≥6.5%, a fasting plasma glucose
level ≥7 mmol/L at least 2 times, or a random glucose level
≥11.1 mmol/L with diabetic symptoms, and at least one of
autoantibodies to islet cell antigens, glutamic acid decarbox-
ylasee (GAD) and Islet antigen-2 (IA-2) or c-peptide level
<0.7 mmol/L at random or <1.1 mmol/L at the peak by a
glucagon test.
Anti-tissue transglutaminase autoantibody_IgA (tTGIgA) and
anti-tissue transglutaminase autoantibody_IgG (tTGIgG) were
measured by using Open tTG-ab Elisa (IgA) and (IgG) kits
(Zedira, Germany). A value of >3.5 U/mL was graded positive.
We genotyped DQB1 using SeCore DQB1 Locus Sequencing
Kits (5341925D, 25Tests/Kit, Invitrogen/Life Technologies,
Brown Deer, WI) on an ABI 3730XL DNA Analyzers (Applied
Biosystems, Foster City, CA) with uTYPE6.0 SBT software
(Invitrogen).
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S85