Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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patients with SMI < 5.4 kg/m2 had higher mortality rate than
those with SMI >=5.4 kg/m 2 (p = 0.014). Moreover, in the Cox
regression analysis adjusted for age, duration of diabetes,
HbA1c, and serum creatinine, SMI was significantly and
inversely associated with the mortality (hazard ratio = 6.39,
95% confidence interval = 1.42 –28.68, p = 0.016).
Conclusion: The present study showed that lower SMI was
associated with the increased all-cause mortality in postme-
nopausal women with type 2 diabetes mellitus, suggesting
that muscle mass reduction is an important complication
which is involved in the risk of mortality in type 2 diabetes.
PB-25
The influence of diabetes on eradication rate of Helicobacter
pylori
Yurika IKEGAMI1, Akahito SAKO2*, Hiroyuki ADACHI2,
Tomoyuki YADA1, Hitohiko KOIZUKA1, Naomi UEMURA1,
Hidekatsu YANAI 2. 1Department of Gastroenterology &Hepatology,
Kohnodai Hospital, National Center for Global Health and Medicine,
2 Department of Internal Medicine, Kohnodai Hospital, National
Center for Global Health and Medicine, Japan
Introduction: The prevalence of Helicobacter pylori (HP)
infection is high in Asia. Although eradication therapy of HP
has been strongly recommended to prevent gastric cancer and
peptic ulcer, several studies reported the lower success rate of
eradication in diabetic patients. We aimed to elucidate the
influence of diabetes and glycemic control on eradication
rate of HP.
Method: We retrospectively investigated the patients who
underwent first line HP eradication therapy (Proton Pump
Inhibitor, Clarithromycin, Amoxicillin) from January 2011 to
December 2013. We excluded the patients who did not
complete the eradication therapy and the assessment test
of HP infection. We collected information about patient
characteristics, smoking history, laboratory data, endoscopic
findings, regimen of HP eradication, status of diabetes, and
anti-diabetic drugs. We compared eradication success group
and failure group by t-test and chi-square test, and used
logistic regression model to analyze the factors associated
with eradication of HP. Study protocol was approved by
institutional review board.
Result: Of the 546 patients who underwent first line HP
eradication from 2011 to 2013, 415 patients were eligible.
Mean agewas 64.2 years old and 192 patients were male. Sixty-
three patients had diabetes and mean HbA1c was 6.9%.
Eradication rate in total was 75.7%. Age, sex, smoking status,
dose of clarithromycin, type of proton pump inhibitor, and
atrophy of gastric mucosa were not significantly associated
with eradication rate. Diabetic patients had significantly
higher eradication rate than non-diabetic patients (85.7% vs
73.9%). In diabetic patients, mean HbA1c before eradication
therapy was not significantly different between eradication
success group and failure group. HbA1c and body mass index
before and after eradicationwere similar. Multivariate analysis
showed that adjusted odds ratio of successful eradication in
diabetic patients was 2.00 (95% confidence interval: 0.86 –4.31,
p = 0.11).
Conclusion: Contrary to previous small scale studies, eradica-
tion rate was relatively better in diabetic patients. We need the
prospective, larger scale study to clarify the relationship
between diabetes and eradication of HP.
PB-26
The glycemic control of adult population in Nauru
Chang-Hsun HSIEH 1*, Samuela KOROVO 2, Silina MOTUFAGA3,
Chun-Jui HUANG 4,5 , Yi-Jen HUNG1. 1Division of Endocrinology
and Metabolism, Department of Internal Medicine, Tri-Service
General Hospital, National Defense Medical Center, Taipei, Taiwan;
2 Naoero Public Health Centre, 3Republic of Nauru Hospital, Republic
of Nauru, Fiji; 4Division of Endocrinology and Metabolism,
Department of Medicine, Taipei Veterans General Hospital, 5Faculty
of Medicine, School of Medicine, National Yang-Ming University,
Taipei, Taiwan
Background: Nauru is one of the countries with high preva-
lence of diabetes mellitus (DM). However, diabetic control
among overall and newly diagnosed DM adult population had
not evaluated in the past.
Methods:This is a retrospective observational cohort study. All
of the data come from the Nauru Diabetes Registry database
from Naeoru Public Health Center from 2011 to 2015. All
patients with their hemoglobin A1C (HbA1C) will be analyzed
and compared between year of 2011–2012 and 2014– 2015.
Results: A total of 614 patients were enrolled for analysis with
mean age of 49.8 year-old and mean diabetic duration of 10.1
years. Themean age of onset of DM is 40.4 year-old. The female
population had long duration of DM than male population.
The overall HbA1C levels are slightly greater in 2014–2015
than 2011–2012 without statistical significance (10.9 ± 2.7 and
10.6 ± 2.2% respectively). The HbA1C levels also do not differ
among DM patients with regular outpatient visits. The
mean HbA1C of newly diagnosed DM is significant higher in
2014–15 than that in 2011–2012 (11.5 ± 2.4 and 10.6 ± 2.1%
respectively, p = 0.039), but not different from HbA1C levels in
2013 in DM patients who received ongoing treatment
(10.9 ± 2.3%). Furthermore, HbA1C worsened significantly in 2
of the 15 districts between 2011–2012 and 2014– 2015.
Conclusions: Nauru has a high prevalence rate with early
onset and inadequately controlled diabetes. It needs to pro-
pose strategy to early detect and improve glycemic control
early to prevent future diabetic complications.
PB-27
Association between CAG repeat length polymorphism of
androgen receptor gene, cardio-metabolic risk factors and
clinical outcomes in Chinese men
Poon Wing WONG1,2*, Andrea O.Y. LUK1,2, Heung-Man LEE1,2,
Eric S.H. LAU1,2, Kitty K.T. CHEUNG 1,2, Alice P.S. KONG1,2,
Ronald C.W. MA1,2, Wing-Yee SO1,2, Juliana C.N. CHAN1,2.
1Department of Medicine and Therapeutics, The Chinese University of
Hong Kong, 2Hong Kong Institute of Diabetes and Obesity Li Ka Shing
Institute of Health Sciences, Hong Kong
Low testosterone is linked to metabolic syndrome and
increased risks of cardiovascular morbidity and mortality.
Cellular effects of testosterone are mediated by its binding to
androgen receptor (AR), and CAG repeat length polymorphism
of receptor gene correlates with its function with longer length
being associated with reduced receptor sensitivity. We
explored the relationship between AR CAG repeat length and
cardio-metabolic parameters, total testosterone levels, and
incident cardiovascular disease (CVD), chronic kidney disease
(CKD) and all-cause death in a prospective cohort of Chinese
men with type 2 diabetes.
From January 2008 to December 2011, 495 men with type 2
diabetes underwent structured assessment of metabolic
profile and complications. DNA was extracted from whole
blood and the region containing AR CAG repeat was amplified
by polymerase chain reaction using primers that flank the
region. Patients were followed for new-onset CVD (coronary
heart disease, stroke, peripheral vascular disease), CKD as
defined by estimated glomerular filtration rate (GFR) <60 mL/
min/1.73 m2, and/or death until 31 May 2016.
In this cohort (mean ± standard deviation [SD] age: 57.9 ± 12.2
years, disease duration: 14.3 ± 7.3 years), CAG repeat number
ranged from 12 to 31 with median of 23 (interquartile range
[IQR]: 21,25). Patients were stratified into two groups bymedian
of CAG repeat number for comparison of risk factors and
outcome. The two groups did not differ with respect to age,
disease duration, total testosterone, anthropometric (body
mass index, waist circumference) and glycaemic (HbA1c,
fasting plasma glucose) indices, but noted that low density-
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S84