Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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(r = 0.254, p < 0.001), BMI (r = 0.175, p = 0.008), and triceps
skinfold thickness (r = − 0.216, p = 0.001). In addition, uric acid
levels were strongly correlated with triglyceride (r = 0.255,
p < 0.001), HDL-cholesterol(r = −0.249, p < 0.001), Apo A(r =
− 0.143, p = 0.033) in Pearson’s correlation. Our data shows
that uric acid levels were correlated with body fat composi-
tions of peripheral as well as central lesion, and lipid profiles in
patients with type 2 DM. Uric acidmay be related to the visceral
adiposity and triglyceride, and help to define a risk factor for
the complications with type 2 DM.
PI-17
Correlation between Computed Tomography indices of
abdominal fat distributions and lipid metabolism in patients
with type 2 diabetes
Jung Kyu PARK 1, Jae Wan KWON1, Eon Ju JEON1, Eui Dal JUNG1,
Ho Sang SHON 1, Ji Hyun LEE1 *. 1Department of Internal Medicine,
Catholic University of Daegu, School of Medicine, Korea
Central obesity is related to lipid metabolism abnormality in
diabetic patients. The aim of this study was to investigate the
relationships between Computed Tomography indices of
abdominal fat distributions and glucose, lipid metabolism in
Patients with type 2 diabetes. Total 642 subjects with type 2
diabetes were enrolled. Abdominal fat amounts were mea-
sured by single slice abdominal computed tomography
scanning. Clinical and anthropometric profile, such as body
mass index (BMI), waist and hip circumferences, waist-to-hip
ratio (WHR), and lipid profile were measured. Triglyceride was
higher in high visceral fat to subcutaneous fat ratio group (V/S
ratio ≥0.4) than in low V/S ratio group (V/S ratio<0.4) (p < 0.001),
and HDL-C was lower in high V/S ratio group than in low V/S
ratio group (p < 0.001).). In pearson ’s correlations, Total
abdominal fat was correlated with HDL-C (r = − 0.192, p < 0.001),
and Triglyceride (r = 0.121, p < 0.002). Visceral fat was corre-
lated with HDL-C (r = −0.305, p < 0.001) and Triglyceride (r =
0.235, p < 0.001). Subcutaneous fat was also correlated with
LDL-C (r = 0.080, p < 0.04). But Visceral to subcutaneous fat
ratio, which is known to be related with cardio-metabolic risk,
was not correlated with Lipid profile (Total cholesterol,
Triglyceride, HDL- and LDL-cholesterol). High Visceral fat to
subcutaneous fat ratio group (V/S ratio≥0.4) have higher
Triglyceride, and lower HDL-C than those in Low V/S ratio
group. Further prospective studies with long-term follow-up
are required to establish a correlation between CT indices of
abdominal fat distributions and lipid metabolism
PI-18
Role of androgen in gender differences in adipocyte fatty
acid binding protein induced by body fat content and
distribution
Xiang HU1, Xiaojing MA1, Xiaoping PAN1, Yuqi LUO1,
Yiting XU 1, Qin XIONG1, Yuqian BAO1*, Weiping JIA1.
1 Department of Endocrinology and Metabolism, Shanghai Jiao Tong
University Affiliated Sixth People ’s Hospital Shanghai Clinical Center
for Diabetes; Shanghai Diabetes Institute, China
Objectives: Adipocyte fatty acid binding protein (A-FABP) is a
transport protein in mature adipocytes. Clinical investigations
have indicated women have higher levels of A-FABP thanmen.
In consideration of sex hormones and body fat content and
distribution, the present study aimed to identify factors related
to gender differences in serum A-FABP levels.
Methods: Serum A-FABP levels were measured by a sandwich
enzyme-linked immunosorbent assay. An automatic bioelec-
trical impedance analyzer was used to measure the fat mass
and percentage of the total body, trunk, arms, and legs.
Results: A total of 507 participants were enrolled, including 194
men, 132 premenopausal women, and 181 postmenopausal
women. SerumA-FABP levels increased in the order frommen
to premenopausal women to postmenopausal women for
participants in both body mass index (BMI) categories
(BMI < 25.0 kg/m2 or BMI ≥ 25.0 kg/m2; all P < 0.05). Spearman
correlation analyses showed that the indexes of the total and
segment body fat were correlated with serum A-FABP levels
significantly in both genders (all P < 0.001). Total testosterone
(TT) and sex hormone-binding globulin (SHBG) displayed
negative associations with serum A-FABP levels in men (all
P < 0.001). In pre- and postmenopausal women, TT, free
testosterone (FT), and bioavailable testosterone (BAT) were
positively associated with serum A-FABP levels (all P < 0.001),
whereas SHBG was negatively (P < 0.001 and P = 0.001, respect-
ively) associated with serum A-FABP levels. Multiple stepwise
regression analyses showed the trunk FMwas an independent
and positive factor of serum A-FABP levels in our sample of
men and pre- and postmenopausal women. For men, TT was
associated independently and inversely with serum A-FABP
levels. For pre- and postmenopausal women, BAT and TT were
independent and positive factors associated with serum A-
FABP levels, respectively. After adjustment for the factors
related to serum A-FABP levels, the associations described
above remained significant.
Conclusion: Serum A-FABP levels increased following the
order of men, premenopausal women, and postmenopausal
women progressively. Androgen was identified as an inde-
pendent and negative factor of serum A-FABP levels in men
and an independent and positive factor of serumA-FABP levels
in women. Based on its effects on fat content, especially trunk
fat, androgen may contribute to gender differences in serum
A-FABP levels.
PI-19
Controlled attenuation parameter (CAP) have close
relationship with the prevalence and the severity of NAFLD in
a T2DM population
Jaehyuk LEE1*, Kwangjun KIM2. 1Seonam University, Myongji
Hospital, 2Yonsei University, College of Medicine, Korea
Background: The severity of non-alcoholic fatty liver disease
(NAFLD) in type 2 diabetes mellitus (T2DM) population
compared with that in normal glucose tolerance (NGT)
individuals has not yet been assessed by a quantitative
method. We investigated the prevalence and the severity of
NAFLD in a T2DM population using controlled attenuation
parameter (CAP).
Methods: Subjects who underwent testing for biomarkers
related to T2DMand CAP using Fibroscan® during a regular
health check-up were enrolled. CAP values of 250 dB/m and
300 dB/m were selected as the cutoffs for the presence of
NAFLD and for moderate to severe NAFLD respectively.
Biomarkers related to T2DM included fasting glucose/insulin,
C-peptide, HbA1c, glycoalbumin, and HOMA-IR.
Results: Among 340 study participants (T2DM, n = 66; pre-
diabetes, n = 202; NGT, n = 72), the proportion of subjects with
NAFLD increased according to the glucose tolerance status
(31.9% in NGT; 47.0% in pre-diabetes; 57.6% in T2DM). The
median CAP value was significantly higher in subjects with
T2DM (265 dB/m) than in thosewith pre-diabetes (245 dB/m) or
NGT (231 dB/m) (all P < 0.05). Logistic regression analysis
showed that subjects with moderate to severe NAFLD had a
2.4-fold (odds ratio) higher risk of having T2DM than those
without NAFLD (P = 0.02; 95% confidence interval, 1.13–4.86),
and positive correlations between the CAP value and HOMA-IR
(ρ = 0.407) or C-peptide (ρ = 0.402) were demonstrated.
Conclusion: Subjects with T2DM had a higher prevalence of
severe NAFLD than those with NGT. Increased hepatic
steatosis was independently associated with the presence of
T2DM, and insulin resistance induced by hepatic fat may be an
important mechanistic connection.
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S187