Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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filtration rate (eGFR) was 86.3 and 92.7 mL/min/1.73 m 2(P =
0.5); mean urine albumin-creatinine ratio (ACR) was 103 and
132 mg/g (P = 0.5); the percentage of retinopathy was 50% and
16.0% (P = 0.006) for patients receiving bariatric surgery
and intensive medical controls respectively. There is no
significantly difference in baseline blood pressures, lipid
profile, or medications. After 12 months of follow-up, patients
receiving bariatric surgery had significantly greater percentage
reduction in BMI (−29% vs 0.3%, P < 0.001, adjusted P < 0.001),
greater percentage reduction in HbA1c ( −32% vs −1%, P < 0.001,
adjusted P < 0.001), greater increase in estimated GFR (24% vs
− 3.5%, P < 0.001, adjusted P = 0.001), greater reduction in urine
ACR ( −8.3% vs 0.1%, P < 0.001, adjusted P = 0.04), and a trend
of greater regression of retinopathy ( −20% vs 1.3%, P = 0.2,
adjusted P = 0.3) as compared to patients receiving intensive
medical control. After further adjustment for HbA1c reduction,
the relative improvement in eGFR remained significant
(P = 0.004) but the improvement in urine ACR is attenuated
(P = 0.11).
Conclusion: Obese/overweight diabetic patients receiving
bariatric surgery have significantly reduced nephropathy
and possibly reduced retinopathy as compared to intensive
medical control.
PI-04
Visceral adiposity index predicts the conversion of
metabolically healthy obesity to an unhealthy phenotype
Woo Je LEE1, Yu Mi KANG1*, Chang Hee JUNG1,
Yun Kyung CHO 1, Jung Eun JANG 1, Jenie Yoonoo HWANG2,
Eun Hee KIM2, Joong-Yeol PARK 1, Hong-Kyu KIM2. 1Department
of Internal Medicine, Asan Medical Center, University of Ulsan
College of Medicine, 2Department of Health Screening and Promotion
Center, Asan Medical Center, University of Ulsan College of
Medicine, Korea
Background: Some individuals with metabolically healthy
obesity (MHO) convert to metabolically unhealthy obesity
(MUO) phenotype, and visceral adiposity is one of proposed
mechanisms underlying such conversion. Visceral adipose
index (VAI) is a novel model which estimates visceral adiposity
based on anthropometric and lipid profiles. We aimed to
determine the association of VAI-estimated visceral adiposity
with the MHO-to-MUO conversion and the predictive value of
VAI in estimating such unfavorable outcomes.
Methods: 5,187 Korean subjects with the MHO phenotype were
enrolled and stratified by body mass index and metabolic
health state according to Wildman criteria at baseline and last
follow-up examinations. VAI was calculated at baseline.
Results: Over a median follow-up period of 37.9 months, 27.6%
of subjects converted to MUO phenotype. Higher VAI quartiles
were associated with a greater proportion of subjects who
underwent MHO-to-MUO conversion, and also with increased
odds ratios for such conversion even after multivariate
analyses. According to ROC analyses, the optimal VAI cut off
value was 1.30, with a sensitivity of 56.1% and a specificity of
64.4% (AUC, 0.636; 95% CI, 0.618–0.654, P < 0.001), and the
predictive value of VAI was superior to that of WC (differences
between areas, 0.072; 95% CI, 0.048–0.096, P < 0.001).
Conclusions: VAI-estimated visceral adiposity is well corre-
lated with the prognosis of MHO subjects, and VAI has a good
predictive value in determining the MHO-to-MUO conversion.
PI-05
Association between human adenovirus-36 infection, obesity
and glycemia in prospective follow-up of Hong Kong Chinese
school children
Alice Pik Shan KONG 1,2,3*, Kai Chow CHOW4, Paul CHAN5,
Chun Kwok WONG 6 , Mary WAYE7, Andrea LUK 1,2,3,
Ronald MA1,2,3, Juliana CHAN1,2,3. 1 Department of Medicine and
Therapeutics, The Chinese University of Hong Kong, 2Hong Kong
Institute of Diabetes and Obesity, The Chinese University of Hong
Kong, 3Li Ka Shing Institute of Health Sciences, The Chinese
University of Hong Kong, 4Nethersole School of Nursing, The
Chinese University of Hong Kong, 5Department of Microbiology, The
Chinese University of Hong Kong, 6Department of Chemical
Pathology, The Chinese University of Hong Kong, 7School of
Biomedical Sciences, The Chinese University of Hong Kong, Hongkong
Increasing evidence suggest a link between obesity and viral
infection. Adenovirus-36 (Ad-36) is the only human adeno-
virus known to be associated with obesity. We aimed to
examine the associations of Ad-36 infection with cardiometa-
bolic risk factors including obesity, glycemia and other obesity
associated cardiometabolic risk factors in school children.
Stored aliquots of Hong Kong Chinese school children from
two territory-wide surveys conducted in 2003 and 2007– 08
were examined for Ad-36 infection using serum neutralization
test for Ad-36 antibodies. The school children were called
back for repeated examinations of their anthropometric
indices and cardiometabolic profile including fasting plasma
glucose and lipid, as well as serum for their Ad-36 antibodies.
A total of 983 school children (41.8% male) were called back
for prospective study. Mean follow-up duration was 8.7 years
(standard deviation, SD = 2.7 years). Mean age of the partici-
pants was 14.0 (SD 3.2) years and 22.7 (SD 4.9) years at baseline
and follow-up respectively. The prevalence of Ad-36 infection
at baseline was 1.5%, while the prevalence increased to 3.3% at
follow-up (p = 0.002). Using mixed-effects model, there was no
significant association between Ad-36 infection status and
obesity and obesity-associated conventional cardiometabolic
risk factors including fasting plasma glucose after adjustment
of age and sex. Likewise, there was no significant association
between Ad-36 infection status and obesity and obesity
associated cardiometabolic risk factors using one-way
ANOVA analysis by comparing BMI with the status of Ad-36
infection. To conclude, the prevalence of Ad-36 infection in
Hong Kong Chinese school children was low and there was no
significant association between Ad-36 infection and obesity,
glycemia and obesity associated cardiometabolic risk factors.
PI-06
Ferulic acid stimulates muscle insulin signaling pathway in
high-fat diet-induced obese mice
Jarinyaporn NAOWABOOT1*, Pritsana PIYABHAN1. 1 Department
of Preclinical Science, Faculty of Medicine, Thammasat University,
Pathum Thani 12120, Thailand., Thailand
Ferulic acid (FA) is a plant phenolic acid that has several
pharmacological effects including antihyperglycemic activity.
Thus, the objective of this study is to investigate the effect of
FA on impaired glucose metabolism in high-fat diet-induced
obese mice. Five-week-old ICR mice were fed with normal or
high-fat (45 kcal% fat) diet for 16 weeks. During the last 8 weeks
of induction, mice were divided into 4 groups of 8 mice each:
normal control mice, obese control mice, and obese mice
treated with FA (25 and 50 mg/kg/day). After 8 weeks of
treatments, FA significantly reduced the elevated blood
glucose and serum insulin levels, and improved glucose
tolerance. Interestingly, FA increased the protein expression of
insulin receptor substrate 1 (IRS1), phosphoinositide-3-kinase
(PI3K), and protein kinase B (Akt) in skeletal muscle tissue of
obese mice. Our findings demonstrate that FA improves
glucose metabolism in HFD-induced obesity by stimulating
the insulin signaling pathway in skeletal muscle tissue.
PI-07
Young women with severe obesity by gastric sleeve resection
of successful weight loss and pregnancy case report
Shuyin MAO1*. 1Nutrition Department, Chimei Medical Center,
Taiwan
Obesity is a problem facing the world today, countries in the
world rising prevalence of obesity problems arising States
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S184