Diabetes Research and Clinical Practice - Volume 120 - Supplement 1

caused considerable health care costs, the case of a 26-year-old

female, height 167 cm, BW: 107 kg, BMI: 38.3, no other chronic

disease, endoscopy have gastroesophageal reflux, abdominal

ultrasound fatty liver, HbA1C: 5.7, working in a convenience

store clerk, working hours Intermediate (12:00 Am

–

20:00 Pm),

because of his living and working outside, eating Indefinite

meals (mostly convenience store diet food such as bread,

Oden, eating dinner time around 21.00 Pm) have a drink and

snack eating habits, weight gain readme States every year

since graduation, 104 inMarch to the hospital linked to general

surgical want Bariatric surgery seek assistance, a number of

checks done after 104 years July 2 to perform sleeve gastrec-

tomy surgery, in stable condition on July 7 to return home,

after eating progress through each texture after about 3 weeks

after the general progress to diet, weight also successfully after

decreasing from 105 in March reduced to 107 by the weight

72.9 Kg (decrease 34.1 kg) BMI: 26 (overweight, especially

severe obesity

→

), while successful pregnancy pregnant five

weeks, this young woman by sleeve gastrectomy surgery and

diet under control, within eight months succeeded in reducing

nearly 30% of body weight, and track the biochemical values

were normal and smooth pregnancy in marriage.

PI-09

The effect of metformin therapy on insulin resistance and

Ferriman-Gallwey Scores in patients with idiopathic hirsutism

Filiz CEBECI

, Meral MERT

*, Nahide ONSUN

Department of

Dermatology and Venereology, Medeniyet University, Göztepe

Education and Research Hospital,

Bakirkoy Dr. Sadi Konuk

Education and Research Hospital, Endocrinology and Metabolism,

Department of Dermatology and Venereology, Bezmialem Vakif

University, Medical Faculty, Istanbul, Turkey

Introduction:

It is well known that hyperandrogenism and

insulin resistance are now closely associated. Our aim was to

investigate the affect of metformin therapy on insulin

resistance and FG scores in overweight presenting with

hirsutism.

Material and methods:

40 overweight women were investi-

gated who applied to outpatient clinic with hirsutism com-

plaint, retrospectively. Hirsutism was defined as Ferriman-

Gallwey (FG) score >8. The diagnosis of IH was based on the

presence of hirsutism, regular ovulatory menstrual cycles, and

a normal serum androgen profile including free testosterone

(normal: 0.04

–

3.9 pg/mL) and dehydroepiandrosterone sulfate

(normal: 35

–

430 μg/dL). There was no history of diabetes

mellitus in the study group. All participants had not used

any medication or oral contraceptives for the last three

months. In the study group, blood sampling was done in the

early follicular phase of spontaneous or induced (by medrox-

yprogesterone acetate 10 mg/day for 7 days) menstrual cycles.

Insulin resistance was calculated with homeostasis model

assessment of insulin resistance (HOMA-IR), using the follow-

ing formula: fasting serum insulin (μU/mL) × fasting plasma

glucose mmol/l)/. All patients were overweight and hyper-

insulinemic. They underwent metformin therapy due to

hyperinsulinemia. Hormone, metabolic, insulin, FG scores

and HOMA-IR scores were investigated at the beginning, 3th,

and 6thmonth of themetformin therapy. SPSS-16 was used for

the statistiscs. Wilcoxon test and pearson correlation were

used for the statistics.

Results:

40 patients (mean age ± 6,14) were evaluated. The

Ferriman-Gallwey score (FG) was significantly differ at the

beginning- 3th and 6th month (p < 0.005). There was only

significant differences between at the beginning and 6th

month of HDL level. There were significant differences

between total testosterone levels at 0,3th and 6th months.

We found significant differences only 0 and 3thmonts of 17OH

levels in patients. There were statistically significant differ-

ences between 0,3th and 6th months glucose, insulin and

homa-IR levels (p < 0.05).

Conclusions:

Insulin resistance should be assessed in all

hirsute women. Metformin therapy is the first choice for insu-

lin resistance. The metformin therapy significantly improved

insulin resistance, imbalance of endocrine hormones, hirsut-

ism and menstrual cyclicity in women even though idiopathic

hirsutism. FG scores and testosterone levels should be

improved with metformin therapy in hiruste women. More

studies in larger numbers of patients should be performed to

investigate the role of insulin resistance in women with IH.

PI-10

Gender difference on the eating styles and the effect of group

diet education in adolescents in Taiwan

Hsiang-Hsun CHUANG

*, Chieh-hsiang LU

1,2,3

Ditmanson

Medical Foundation Chia-Yi Christian Hospital,

Department of

Business Administration, College of Management, National Chung

Cheng University,

Department of Nursing, DAYEH University,

Taiwan

Objective:

Nowadays, the issue of school children obesity and

metabolism syndrome is getting more pressed and continues

to draw attention. It is known that Chia Yi has the highest rate

of school children obesity in Taiwan. Therefore we focus this

issue on the adolescents aged 13

–

14 in Chia-Yi region and

conduct a study on the eating styles of the subjects, with a

focus on the food they consumes and theway they eat relate to

body weight. We also strive to investigate if diet education

according to group characteristics based on the results we

obtained could succeed in reducing obesity andmaintain body

weight control in school children. This might prove useful for

establishing guidelines for body weight control.

Method:

Group of 89 obese students with a mean BMI of 27.28

were analyzed on the effect of co-ed on body weight reduction.

Results:

Of both the girls and boys, the following factors were

found to have influence on body weight statistically, including

meal frequency, school lunch intake, bed time, water intake,

vegetable consumption, fried food consumption, rice intake,

snack food intake, how fast they eat, bowel movement.

On the co-ed effect on body weight reduction. There are three

classes, one with both girls and boys(co-ed), the other two

classes with either girls or boy only. With the same mean

BMI of 27.28 and being led by the same teacher on skills of

nutrition improvement and physical fitness for one semester,

significant difference of BMI reduction was found. The girls

only class achieved a lower BMI (1.89 reduction) than boys only

class (1.12 reduction), while the co-ed class achieved the least

(0.67 of BMI reduction).

Conclusions:

The eating styles of school girls and boys were

different in chia-Yi region. For the obese students in the

context of group diet education, gender conscience has a role

in achieving body weight reduction. It is conjectured that

competitiveness could be heightened and lead to better result

in class of the same sex only, esp in girls. This hints that gender

segregation might be useful in achieving better weight

reduction.

PI-11

Decreased serum betatrophin levels after Roux-en-Y gastric

bypass in obese Chinese patients with type 2 diabetes: a 1-year

follow-up

Kaifeng GUO

, Haoyong YU

, Junxi LU

, Yuqian BAO

Haibing CHEN

, Weiping JIA

Shanghai Jiao tong University

Affiliated Sixth People

’

s Hospital, China

Background:

There is increasing evidence that serum beta-

trophin levels, a hormone derived from adipose tissue and

liver, are elevated in type 2 diabetes mellitus (T2D).

Objective:

To investigate the relationships between betatro-

phin and metabolic control, insulin resistance (IR), and

pancreatic

-cell function in obese Chinese patients with T2D

who underwent Roux-en-Y gastric bypass (RYGB).

Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65

–

S211

S185