Diabetes Research and Clinical Practice - Volume 120 - Supplement 1

nutrition counseling on glycemic control and cognitive

function in type 2 diabetic patients.

Methods:

This was a cross-sectional study. The participants

were recruited from a systematic sampling of Keelung

Hospital, Ministry of Health and Welfare, R.O.C. Patients who

have history of type 2 DM for more than 10 years, aged between

50 and 70 years, and treated and followed by an endocrinolo-

gist were enrolled in the study. The patients who had received

nutritional counseling were allocated into the intervention

group (N = 26), and those hadn

’

t received nutritional counsel-

ing were allocated into the control group (N = 13). The

questionnaires of diet were collected to estimate the effect-

iveness of nutrition intervention by registered dietitian. The

Mini-Mental State Examination (MMSE) was used as a tool to

quantify cognitive capacity by psychiatrists. The body mass

index (BMI) and metabolic profiles including glycated hemo-

globin A1c (HbA1c), blood glucose, total cholesterol and

triglyceride.

Result:

All thirty-nine patients had completed the study

measures and all of the data had been corrected for statistical

analysis. The questionnaires score was significantly higher in

the intervention group than the control group (p < 0.02).

Although HbA1c in the intervention group was lower than

the control group, there was no significant difference. There

were also no significant differences in total cholesterol,

triglyceride, BMI and MMSE score between the two groups.

Conclusion:

Nutrition counseling can improve understanding

of diet therapy in patients with type 2 DM. Long term follow-up

is mandatory to clarify the effect of nutrition counseling on

BMI and metabolic profiles.

PE-66

The effects of different Korean red ginseng fractions on

diabetic progression and diabetic complication markers in

obese diabetic NSY/Hos mice

Jong Suk PARK

*, Ji Hong YOU

, Sang Bae LEE

, Min Young LEE

Eun Jung KIM

, Min Jin KIM

, Min Kyung KIM

, Yu-Sik KIM

Ji Sun NAM

, Shinae KANG

, Chul Woo AHN

, Kyung Rae KIM

Gangnam Severance Hospital, Korea

Object:

Although Korean red ginseng (KRG) has been shown

positive effects on glycemic control by improving insulin

sensitivity and insulin secretory functions, the distinct roles of

its specific fractions (saponin, SFR; or non-saponin, NSFR) is

unclear. Moreover, the protective roles of KRG and its fractions

on the transition from pre-diabetes to diabetes have been

merely investigated. This study examined the effects of KRG,

SFR and NSFR on various metabolic parameters in obese

diabetic NSY/Hos mice

Methods:

12-wk-old NSY/Hos mice were fed 200 mg/kg/day or

400 mg/kg/day of KRG extract (KRG200, KRG400), SFR (SFR 200,

SFR 400) or NSFR (NSFR 200, NSFR 400) in their diets for 24

weeks. The parameters for glucose homeostasis, diabetic

complications, obesity, inflammation and oxidative stress

were measured.

Results:

KRG200 showed significantly lower fasting blood

glucose; KRG200 and KRG400 showed significantly attenuated

glucose intolerance in response to intraperitoneal glucose

loading; SFR 200 and SFR400 showed significantly increased

insulin secretory response to glucose as measured by insuli-

nogenic index (IGI); KRG400, SFR 200, SFR400, NSFR 200, and

NSFR 400 showed significantly attenuated oxidative stress

parameter as measured by oxidized LDL-C; KRG400, SFR 200,

and SFR400 showed attenuated diabetic blood-vessel compli-

cation marker as measured by advanced glycation end

products (AGEs). (*all p compared to the non-treated control)

Conclusion:

Although KRG, NSFR, NSFR 400 were not able to

prevent transition from prediabetes to diabetes, KRG appeared

to be more effective in glycemic control. However, each

fraction may attenuate hyperglycemia-related complications

to the different extent.

Psychosocial Status of Diabetes: What

Have We Learned? Psychosocial

Perspectives on Diabetes Caring and

Health Behavior

PF-01

HbA1c is not a biomarker for depression in the era of DPP-4

inhibitors

Sunao MATSUBAYASHI

*, Akihiro MATSUBARA

Yumi TAKEDA

, Hitoki MIYAI

, Takeshi HARA

Department

of Psychosomatic Medicinc, Fukuoka Tokushukai Medical Center,

Japan

Patients who have both depression and diabetes mellitus (i.e.

diapression) have the characteristics of poor glycemic control,

high psychological stress and poor adherence to anti-diabetic

medicine. Since 2009, DPP-4 inhibitors have become available

for prescription in Japan. We did a cross-sectional study on 151

diabetic patients with regard to diapression at the Department

of Psychosomatic Medicine, Fukuoka Tokushukai Medical

Center in July 2013. Among the 151 diabetic patients, 22

non-type 2 diabetic patients were excluded, and the remaining

129 type 2 diabetic patients whomet the inclusion criteriawere

asked to fill out 2 questionnaire surveys, the Beck Depression

Inventory (BDI) and Fisher

’

s Diabetes Distress Score (DDS).

We conveniently categorized BDI

≥

16 as depression group

and BDI < 16 as non-depression group, we then compared the

clinical features of the two groups. We retrospectively

examined the HbA1c data of the 129 patients for 2 years from

the day of survey of each patient. Despite the fact that the

prevalence of diapression in 2013 was almost the same as

previous study, we did not find a statistical difference in HbA1c

between the depression and non-depression group. However,

when we retrospectively examined the HbA1c data for 2 years

since 2013 we found HbA1c from the depression group was

higher than that from the non-depression group. We speculate

that after DPP-4 inhibitors were made available for prescrip-

tion in Japan, the HbA1c readings in the depression-group has

improved. Thus, it might be difficult to detect diapression by

looking at HbA1c alone. In order to look for patients with

diapression, we need to use questionnaire survey tools such as

BDI and DDS.

PF-02

Finding patients who do not have a sense of urgency to

improve hyperglycemia

Yusuke KABEYA

*, Junko UCHIDA

, Masuomi TOMITA

Takeshi KATSUKI

, Yoichi OIKAWA

, Akira SHIMADA

Yoshihito ATSUMI

Tokai University Hachioji Hospital,

Tokyo

Saiseikai Central Hospital,

Saitama Medical University,

Eiju

General Hospital, Japan

Objectives:

Achieving an optimal blood glucose levels is

essential for diabetes treatment. Although most patients

make efforts to control blood glucose levels, there are some

who do not take actions against hyperglycemia, which could

eventually lead to the development of diabetic complications.

Finding such patients as early as possible and encouraging

them to modify their behaviours might be important

in diabetes practice. In this study, we described the pre-

valence of patients who do not have a sense of urgency to

improve their blood glucose levels and investigated their

characteristics.

Methods:

A total of 1,262 diabetic patients who regularly

visited Saiseikai Central Hospital and completed the

Diabetes Treatment Satisfaction Questionnaire were included.

In the questionnaire, the following question was asked; how

often have you felt that your blood sugars have been

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