Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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organisations adopting client-centred approaches that
empower individuals to build confidence and take responsi-
bility of their health.
Despite high rates of type 2 diabetes and diabetes-related
complications in Aboriginal communities, there is a lack of
evidence based diabetes self-management programs designed
for Aboriginal people. The DESMOND program is an evidence-
based, quality diabetes self-management program where
participants are supported to discover/share knowledge of
their personal journey with diabetes.
The Diabetes Education and Self-Management Ongoing and
Newly Diagnosed (DESMOND) program is one example of this.
DESMOND is a client-centred diabetes education program
that uses innovative adult learning theories and philo-
sophies to build confidence, skills and promote diabetes
self-management. Diabetes WA is trialling the effectiveness
of the program, and this approach, in Australian Aboriginal
communities.
Aim: This project aims to explore the cultural fit, effectiveness
and sustainability of delivering DESMOND in Aboriginal
communities.
Method: Diabetes WA developed and strengthened partner-
ships with a number of health services across the state of
Western Australia to enable DESMOND trained diabetes
educators to deliver the program to Aboriginal communities
in Perth and regional Western Australia. Following comple-
tion of the program, attendees were invited to share their
experience of DESMOND, its cultural fit and what changes they
would recommend to improve the program.
Results: Qualitative data was collected and preliminary results
show that Aboriginal participants felt respected by educators
and open discussions, storytelling and hands-on activities
were enjoyable. A number of minor adjustments have been
made to the program, with the length of the program, access to
biomedical results, and appropriateness of foods used pre-
senting challenges. Evaluationmeasures are currently in place
to assess participant ’s HbA1c, cholesterol and blood pressure
three to six months post program.
Discussion: Adapting the DESMOND program to meet the
needs of Aboriginal and Torres Strait Islander people has
the potential to slow the progression of diabetes, impact
biomedical results, and lead to a reduction in diabetes-related
complications. Additionally the results of this trial will con-
tribute to best practice evidence on effective, sustainable
chronic disease education for Aboriginal communities.
PE-63
A novel scoring system for the early detection of diabetic
kidney disease in patients with type 2 diabetes
Chih-Hung LIN1,2, Tzu-Ling TSENG3, Wei-Ya LIN3,
Hsiang-Chi WANG3, Lee-Ming CHUANG1,2 *. 1Graduate Institute
of Clinical Medicine, College of Medicine, National Taiwan University,
2 Department of Internal Medicine, National Taiwan University
Hospital, Taipei, 3Bio Preventive Medicine Corp., Hsinchu, Taiwan
Background: Diabetic kidney disease (DKD) is one of the most
common diabetic complications, as well as the leading cause
of end-stage renal disease (ESRD) worldwide. At present,
urinary albumin-to-creatinine ratio (UACR) and estimated
glomerular filtration rate (eGFR) are the standard diagnostic
methods for DKD. However, their accuracies are limited
due to the heterogeneous disease nature, especially in type
2 diabetes (T2DM). DN_Score is a scoring system generated
from the profiles of DNlite, a urinary biomarker panel
composed of alpha2-HS-glycoprotein precursor (AHSG),
alpha-1-antitrypsin (A1AT) and acid-1-glycoprotein (AGP). In
this cross-sectional study, we investigated the correlation
between DN_Score and clinical profiles of patients with T2DM,
in order to evaluate its potential for diagnosis of DKD.
Methods: 308 patients with T2DM and UACR <300 mg/g
were enrolled in this study. Phenotypic and biochemistry
profiles were recorded. DN_Score was calculated according
to the urinary DNlite profile. UACR and the composite
Kidney Disease Improving Global Outcomes (KDIGO) classifi-
cation system were used for assessing the severity and risk
of DKD.
Results: There were 174 male and 134 female participants.
The mean age was 60.64 ± 9.84 years. The mean DN_Score
was 10.69 ± 0.9. The DN_Score in participants with UACR <30
and ≥30 mg/g was 10.42 ± 0.72 and 11.89 ± 0.63, respectively
(P < 0.01). While classified by the KDIGO system, the DN_Score
in participants with low, moderate-increased, high and very-
high risk was 10.41 ± 0.72, 11.74 ± 0.7, 12.56 ± 0.29, 12.19 ± 0.03,
respectively (P < 0.01). Intercorrelations of DN_Score were
found with BMI, ACR, eGFR, blood pressure, fasting plasma
glucose, HbA1c and plasma triglyceride level. After adjustment
for significant covariates, DN_Score was significantly asso-
ciated with UACR (P < 0.01)
Conclusions: DN_Score is correlated significantly with the
traditional indicators of DKD in the early stage of the disease.
Long-term outcome study will be necessary to validate the
predictive role of DN_Score on the progression of DKD.
PE-64
The relationship between CVR-R and 2-year glycemic control
in type 2 diabetic patients
Kaoru ISO1*, Keiichi MUKAI 2, Yuuki KAKUMAE1 , Koji ISHI1,
Hiromi OHUCHI1. 1Tokyo Kamata Medical Center, 2Yokohama
Shinmidori General Hospital, Japan
Background: Diabetic autonomic neuropathy (DAN) is a
manifestation of diabetic neuropathy. DAN is frequently
observed in patients with a long duration of diabetes and
causes various symptoms once it advanced.
Autonomic nerve dysfunction can be expressed quantitatively
by a coefficient of variation in R-R intervals (CVR-R).
Objective: The aim of the study was assess the relationship
between the autonomic nerve disturbance and glycemic
control in type 2 diabetic patients.
Material and Methods: Fifteen patients (male 7, female 8) with
uncontrolled type 2 diabetes were enrolled.
All patients firstly were received with intensive insulin
therapy.
HbA1c were measured every 2 month. ECGs were recorded in
the resting position and 100 consecutive R-R intervals were
processed computer. CVR-R were measured at baseline and 2-
year later.
Results: At baseline, age, duration, BMI and HbA1c were 63.9
years old, 9.9 year, 24.2 kg/m2 and 10.3%.
The mean HbA1c was significantly lower in 1-year’s (6.9%) and
2-year’s (6.9%) than the baseline ’s.
CVR-R was significantly higer in 2-year’s (3.00%) than the
baseline’s (2.02%).
Conclusion: These results suggest that long-term glycemic
control may ameliorate diabetic autonomic neuropathy.
PE-65
The effect of nutrition counseling on glycemic control and
cognitive function in type 2 diabetic patients
Chia-Hsin YU1, Po-Wen YANG2, Yu-Pei SUNG2,
Cheng-Hsueh CHIEN1, Lin-Hui LI1, Huang-Yu CHANG1,
Shyh-Hsiang LIN3*. 1Department of Dietetics, Keelung Hospital,
Ministry of Health andWelfare, 2Internal Medicine, Keelung Hospital,
Ministry of Health and Welfare, 3School of Nutrition and Health
Sciences, Taipei Medical University, Taiwan
Objective: It’s known that blood glucose was associated with
cognitive function in animal studies. In addition, poor
glycemic control has emerged as a possible risk factor for
cognitive decline among elderly adults with diabetes mellitus
(DM). Medical nutrition therapy is important in managing
DM. The aim of this study was to evaluate the effects of the
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S150