Diabetes Research and Clinical Practice - Volume 120 - Supplement 1

and nutrition supply. We altogether treated this patient, and

the diabetic foot ulcer was healed eventually.

PE-53

Periodontitis prevention program effectively reduced the

incidence of periodontitis in diabetic patients

Yen-Tzu LEE

*, I-chieh MAO

, Shih-Te TU

Lukang Christian

Hospital, Taiwan

A five-year follow up conducted by Firatli found that, clinically,

the number of cases of periodontal attachment loss and teeth

loss among diabetic patients is significantly bigger compared

to people without diabetes. To address the situation, establish

a periodic periodontitis screening and care system for diabetic

patients and have set up a designated screening site. Diabetes

educators help patients learn information about periodontitis

and oral care and provides prompt and proper individual

medical interventions to reduce the possibility of teeth loss or

chewing disorders caused by periodontitis and to enhance

diabetic patients

’

overall health condition. The rate of dental

abnormalities among diabetic patients found in screening had

gone down from 51.9% to 29.9%. This improvement shows that

promulgating oral care allows diabetic patients to take this

issue seriously and care more about their oral condition.

Executing Approach:

1. Establish a cross departmental diabetic periodontitis

screening team comprise of Dentistry and Health

Education Center; members include dentists, physicians

of Diabetes Shared Care Network, diabetes educators, oral

health educators and administrative assistants to jointly

carry out

“

Diabetic Periodontitis Prevention Program

”

2. To prevent patients fromwithdrawing from screening due

to lengthy waits, a designated periodontal screening site

besides the education center is set up.

3. Professional oral health educators will later on provide

education and relevant instructions and arrange patients

with abnormal screening results to receive treatment at

Dentistry outpatient clinics.

4. On patients

’

clinic visits, attending physicians that have

written the request sheet to their patients can look up the

screening results and give instructions to them while

informing them of the importance of oral health or of the

prevention of periodontal diseases.

ProgramAchievement:

12 oral healthcare promulgation events

attracted 344 community members to participate in. The

number of diabetic patients receiving screening between

August 2012 and June 2015 was 4,012. Comparing the screening

achievement in 2014 with that in 2013, the rate of dental

abnormalities among diabetic patients found in screening had

gone down from 51.9% to 29.9%.

Conclusion:

The execution of Diabetic Periodontitis Prevention

Program has not only raised the awareness of oral care and

knowledge and skills about self-care among periodontitis

high-risk group: diabetic patients, its promulgation of screen-

ing has also helped identify periodontitis patients and helped

them seek medical attention. The care provided by Diabetes

Case Management annually tracks and reminds patients to

receive screening and treatment.

PE-54

Associations of glycated hemoglobin A1c and glycated

albumin with subclinical atherosclerosis in the Chinese

population with impaired glucose regulation

Xiaojing MA

, Yun SHEN

, Xiang HU

, Hang SU

, Yaping HAO

Yuqi LUO

, Junling TANG

, Jian ZHOU

, Yuqian BAO

Weiping JIA

Department of Endocrinology and Metabolism,

Shanghai Jiao Tong University Affiliated Sixth People

’

s Hospital;

Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute,

Shanghai, China

Objective:

Glycated hemoglobin A1c (HbA1c), which can reflect

the mean blood glucose levels over the previous 2 to 3 months,

attaches great importance to the glucose monitoring system.

Some new indicators, such as glycated albumin (GA) with

ability to reflect the blood glucose levels during the previous 2

to 3 weeks, have been gradually put into clinical application

and provided HbA1c with complementary information in

recent years. The aim of this study was to investigate the

associations of HbA1c and GA with subclinical atherosclerosis

in middle-aged and elderly Chinese subjects with impaired

glucose regulation.

Methods:

A total of 640 subjects with impaired glucose

regulation and without history of cardiovascular disease or

carotid artery plaque in Shanghai community were recruited

for this study (256 men and 384 women; age range, 40 to 70

years old). Carotid ultrasonography was used to measure the

carotid intima-media thickness (C-IMT), which was an indi-

cator of subclinical atherosclerosis. Increased C-IMT was

defined as

≥

0.70 mm (the upper quartile). HbA1c was deter-

mined by high-performance liquid chromatography. Serum

GA was assayed using the enzymatic method.

Results:

The HbA1c and GA levels were higher in subjects

with increased C-IMT than those with normal C-IMT (both

P < 0.01). Correlation analysis revealed that both HbA1c and

GA were positively associated with C-IMT (r = 0.135 and 0.112,

respectively; both P < 0.01). Logistic regression analysis

showed that both HbA1c (odds ratio = 2.630, 95% confidence

interval: 1.401

–

4.935; P = 0.003) and GA (odds ratio = 1.215, 95%

confidence interval: 1.008

–

1.466; P = 0.041) were independent

factors associated with increased C-IMT.

Conclusions:

In middle-aged and elderly Chinese subjects

with impaired glucose regulation, both elevated levels of

HbA1c and GAwere associated with increased C-IMT, suggest-

ing that HbA1c and GA could reflect the risk of subclinical

atherosclerosis.

PE-55

Asymmetric Dimethylarginine correlates significantly with

tumour necrosis alfa but not with brachial ankle pulse wave

velocity in the T2DM-METS

Deasy ARDIANY

*, Soebagijo ADI

Askandar TJOKROPRAWIRO

, Ari SUTJAHJO

Agung PRANOTO

, Sri MURTIWI

, Sony WIBISONO

Surabaya

Diabetes and Nutrition Centre - Dr. Soetomo Teaching Hospital

Faculty of Medicine Airlangga University, Surabaya, Indonesia

Background:

Endothelial dysfunction is an important

phenomenon in the pathogenesis of atherosclerosis and is

related to the derangements of nitric oxide (NO) synthase in

the vessel wall. Asymmetric Dimethylarginine (ADMA) is an

endogenous, competitive inhibitor of nitric oxide synthase

and is induced by inflammatory cytokines of tumour necrosis

factor (TNF)-a in vitro. Increased ADMA levels are associated

with reduced NO synthesis as assessed by impaired endothe-

lium-dependent vasodilatation. There is cause and effect

relationship between endothelial dysfunction and vascular

stiffening. Measurement of brachial ankle pulse wave velocity

(baPWV) is simple and applicable for cardiovascular risk

screening and as a marker for the severity of atherosclerotic

vascular damage.

Aim:

To investigate the correlation between ADMA level

with TNF-a and baPWV in the type-2 diabetes mellitus

(T2DM)-Metabolic Syndrome (Mets) patients.

Method:

This is a cross sectional study with T2DM-Mets

patients who came to the outpatient clinic of Soetomo

Hospital Surabaya during January 2010 to December 2012.

Subjects met the inclusion and exclusion criteria were

measured their ADMA, TNF-a, and blood glucose levels in

plasma. Brachial ankle pulse wave velocity (ba-PWV) was

determined by using the V Serra-1000. The study was approved

Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65

–

S211

S147