Diabetes Research and Clinical Practice - Volume 120 - Supplement 1

Using Big Data for Research and Care in

Diabetes

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Big data from bench to bedside to population in diabetes care

Deanna FRANCES

, Benjamin PARKER

, Rima CHAUDHURI

Samantha HOCKING

, David E. JAMES

Charles Perkins Centre

and School of Life and Environmental Sciences, Sydney University,

Australia

The future in diabetes care promises to move from a more

generic form of care to treatment that is better tailored

toward the individual. To achieve this it is essential to begin

to define the principles that govern individual responsiveness

to the environment (i.e. food and exercise) as well as to drugs

so that health practitioners can better match optimized

treatments with improved long term health. This will require

analysis of multiple layers of metabolic systems such as the

genome, the transcriptome, the proteome and the environ-

ment using a range of model systems as well as interdis-

ciplinary approaches to define the underlying features that

determine key biological outcomes. This will include advances

in accurate data acquisition, better ways of integrating

data from different labs/centres and across different omic

platforms and advances in data analysis and visualization.

I will describe our efforts to map individual diversity

in response to diet using different genetic strains of flies,

mice and humans. I will describe omics analysis in both

Drosophila and mice of different genetic backgrounds that

clearly highlight the immense complexity of the gene-diet

interaction. By marrying these data with longitudinal analysis

of humans it should be feasible to develop a suite of

biomarkers that predict future health outcomes and optimal

prevention strategies for individuals. Such a venture will

necessitate a move toward

“

big data

”

medical care where

individuals are empowered with personalized data that

provides them with better options for long term health.

Key Collaborators:

Dr Jean Yang, Maths and Stats, USyd

Jake Lusis, UCLA, USA

Brian Drew, Baker IDI, Melbourne Australia

Greg Neely, CPC, USyd, Australia

Jerry Greenfield, Garvan Institute, Sydney, Australia

Rong Zeng, Shanghai Institute of Biological Science, China

WPR Disaster Program

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IDF WPR natural disaster program: What next?

Sidartawan SOEGONDO

, Lee Ming CHUAN

International

Diabetes Federation Western-Pacific Region Disaster Program

The International Diabetes Federation Western-Pacific Region

(IDF-WPR) Disaster Program aims to help each member

country develop disaster preparation and medical care strat-

egies, and thusminimising the effects of disaster events on the

lives and health of diabetic patients by preparing and publish-

ing an important guideline for disaster management. Since the

WPR is known as the

“

Epicenter of the Diabetes Epidemic

”

because 8 of the top 10 countries with the highest prevalence

of diabetes are from the Western Pacific Region. It is not only

significantly affected by the diabetes epidemic, it has also

the most frequently occurring natural disasters and many

people

’

s lives and health, with or without diabetes, are

affected by the disasters. After these disasters, not only do

mortality and morbidity rates immediately increase, but the

stress, infections, lack of food, water, and medications can all

lead to worsening of chronic illness, and may seriously impact

their disease management. A better disaster management

plan for preparation, action, response, and recovery is

essential to reduce the effects of a disaster incident. It is well

recognised that major disasters have a significant impact on

diabetes, both in the short and long terms. Some of the

information which are mentioned in the IDF-WPR Region

Program for Diabetes Management in Natural Disaster are: For

diabetes care providers, and related organisations, and gov-

ernments, should: (i) develop a disaster guideline for emer-

gency with periodic rehearsal assessments before a disaster,

(ii) cooperate and communicate closely with coordination of

medical resources during a disaster, and (iii) review the

response after the disaster events. The IDF-WPR Disaster

Committee aims to assist each country to create a national SOP

for diabetes management in natural disasters. The SOP

includes: (1) Educating diabetic patients and their family

members to prepare for disasters. Conducting a registry of

the diabetic populations most vulnerable after disaster events.

Developing a disaster diabetes care program for medical staff.

Conducting surveys on the quality and quantity of medical

resources for diabetic care, and creating guidelines for

coordinating donations of equipment and medicine from

other countries. Cooperating and communicating with gov-

ernments and various relief organisations. Establishing an

information network to support diabetic patients. (2)

Facilitating the sharing and exchange of information among

researchers and educators throughout WPR-Asia. (3) Through

relationships with the IDF and other collaborative organisa-

tions, providing education to support diabetic people and aid

their recovery from disaster situations. The program also has

flow diagrams for disaster preparation and response at certain

timelines: 1

. For patients with diabetes

: Up-dated lists at

all times: Medications and other major health problems,

emergency food supply, emergency medical supply kit.

Planning: Create a personal evacuation plan and evacuate

early if authorities advise evacuation, learn stress-manage-

ment skills and complete education projects, physician and

emergency contact information, such as phone number, e-

mail address, and name of contact persons. Response during

disaster: Adhere to usual medications and recommended diet

and lifestyle as much as possible, regularly self-monitor blood

glucose and blood pressure, and perform other forms of self-

management, such as wound care. Resolution and recovery:

Ensure that appropriate meals are provided to diabetic

patients (meals in shelters can be inappropriate for diabetes

patients and impaired glucose control), ensure that diabetic

patients maintain their daily activities and prevent becoming

bedridden, which would reduce quality of life.

2. For diabetic

medical staff:

Before disaster

: Make an emergency plan: Appoint

a leader and deputy to oversee preparation and operations,

procure and maintain emergency equipment and supplies

with standardised resource request correctly, periodic

rehearsal and assessment. Guideline development and staff

training and preparation: Develop training projects for medical

and paramedical staff, including physicians, nurses, dieti-

cians, pharmacists, and social workers, etc. Organise multi-

disciplinary medical teams for diabetes care.

Response during

disaster

: Help network coordination and assist to provide

comprehensive care, including mental health support, to

patients, manage glucose, blood pressure, and evaluate and

manage acute and chronic diabetic complications and other

related medical problems, educate patients on self-manage-

ment.

Resolution and recovery:

Support people recovering from

disaster situations, and assist to provide long-term, continu-

ous, and comprehensive care, regularly evaluate the health

of each diabetic patient and provide support to prevent the

acute complications and worsening of chronic conditions.

For government and diabetes organisation:

Before disaster:

Speech Abstracts / Diabetes Research and Clinical Practice 120S1 (2016) S1

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