Diabetes Research and Clinical Practice - Volume 120 - Supplement 1

and use of antiplatelet drugs (OR = 0.197, p = 0.08). In a multiple

linear regression analysis, TIMP-1 (95%CI: 0.007

–

0.003; p = 0.01)

was independently associated with CPS in patients with T2DM

and HTN after adjustment of confounding risk factors.

Conclusions:

These results suggest that TIMP-1 is associated

with CPS in patients with T2DM and HTN.

PE-10

Influencing factors of intention to receive examination of

diabetes complications

Yi-Lin HSIEH

, Fang-Hsin LEE

*, Shiau-Jia WEN

, Pei-Yu CHIU

Tsui-Hsien TSAI

, Sheng-Che LIN

Community Health Center,

Tainan Sin-Lau Hospital, the Presbyterian Church in Taiwan,

Department of Nursing, Chung Hwa University of Medical

Technology,

Public Health Bureau, Tainan City Government, Taiwan

Aims and objectives:

To understand the situation of diabetes

patients receiving examinations for diabetes complications

and to explore the factors influencing diabetes patients

’

intention to receive examinations for diabetes complications.

Background:

Diabetes mellitus is an important health topic

worldwide, and receiving examinations for diabetes complica-

tions periodically can aid in early detection and early

treatment of diabetes complications.

Design and methods:

It was a cross-sectional study that

included a total of 251 diabetes patients who visited outpatient

clinics of metabolism departments in Tainan.

Results:

The percentages of participants who received fundus,

foot, and kidney examinations were 67.7%, 61.4%, and 73.3%,

respectively. Every point increase on the perceived barriers to

taking action to receive diabetes complication examinations

scale increased the intention to receive foot examination in

the following year by 0.911 times (p = 0.002), and every point

increase on the perceived susceptibility to diabetes complica-

tions scale increased the intention to receive kidney examin-

ation in the following year by 1.195 times (p = 0.045).

Conclusion:

A higher level of perceived barriers to taking

action to receive diabetes complication examinations reduced

the intention to receive foot examination in the following year,

and a higher level of perceived susceptibility to diabetes

complications. Medical personnel should take the responsi-

bility to increase the intention to receive examination of

diabetes complications.

Relevance to clinical practice. The results of this study can

promote medical personnel

”

care efficacy in preventing

diabetes complications and can provide medical institutions

with reference to establish prevention and control policies for

diabetes complications.

PE-11

Inflammation associated with intraocular pressure in the

subjects with metabolic syndrome

I-Te LEE

*, Wayne H.-H. SHEU

, Shih-Yi LIN

, Jun-Sing WANG

Chia-Po FU

, Chia-Lin LEE

Division of Endocrinology and

Metabolism, Department of Internal Medicine, Taichung Veterans

General Hospital, Taichung, Taiwan

Intraocular pressure is associated with metabolic syndrome, a

cluster of cardiovascular risk factors. CRP was reported,

independent of metabolic syndrome, to be associated with

cardiovascular disease. In the present study, we examine the

effect of CRP on subjects with or without metabolic syndrome.

The subjects underwent physical check-up were enrolled for

intraocular pressure and serum CRP measurements.

A total of 1041 subjects were enrolled in this present study. The

intraocular pressure was significantly higher in the subjects

with metabolic syndrome than those without (14.1 ± 3.0 vs.

13.4 ± 3.0 mmHg, P = 0.002). The intraocular pressures were

also significantly different among the subjects with different

CRP tertiles. The highest intraocular pressure was in the

subjects with metabolic syndrome and highest CRP tertile; the

lowest intraocular pressure was in the subjects with lowest

CRP tilter and without metabolic syndrome (P value for trend

<0.001). CRP, independent to metabolic syndrome, was an

independent risk factor for high intraocular pressure (95%CI

between 0.080 and 1.297, P = 0.027) in multivariate linear

regression analysis.

In conclusion, systemic inflammation, present by serum CRP,

is associated with high intraocular pressure.

PE-13

Current metabolic status affects urinary liver-type fatty-acid

binding protein in patients with type 2 diabetes

Hiroyuki ITO

*, Hitomi YAMASHITA

, Mina NAKASHIMA

Haruki FURUKAWA

, Akifusa TAKAKI

, Chiduko YUKAWA

Suzuko MATSUMOTO

, Takashi OMOTO

Masahiro SHINOZAKI

, Shinya NISHIO

, Mariko ABE

Shinichi ANTOKU

, Mizuo MIFUNE

, Michiko TOGANE

Department of Diabetes, Metabolism and Kidney Disease, Edogawa

Hospital,

Laboratory Department, Edogawa Hospital, Japan

Aims:

We aimed to study the association between urinary

liver-type fatty acid-binding protein (L-FABP), a biomarker

of tubulointerstitial injury, and the clinical characteristics of

normoalbuminuric and albuminuric patients with type 2

diabetes in order to detect the factors affecting urinary L-FABP.

Methods:

Urinary L-FABP levels were measured in 788 [466

normoalbuminuric (urinary albumin-to-creatinine ratio (ACR)

<30 mg/gCr) and 322 albuminuric (urinary ACR

≥

30 mg/g)]

patients with type 2 diabetes, and again in 666 patients who

continued to visit our department for a six-month period after

the initial measurement. The association between the urinary

L-FABP level and the clinical parameters was investigated.

Results:

Both the urinary L-FABP concentration and the

frequency of high urinary L-FABP (>8.4 μg/gCr) became signifi-

cantly higher (P < 0.01) with the progression of ACR. The HbA1c

(OR: 1.42, 95% CI: 1.11

–

1.79, P < 0.01), systolic blood pressure

(OR: 1.03, 95% CI: 1.01

–

1.05, P < 0.01) and estimated glomerular

filtration rate (OR: 0.98, 95% CI: 0.96

–

1.00, P = 0.01) levels were

significantly associated with the high urinary L-FABP in

normoalbuminuric patients after a forward stepwise selection.

However, a logistic regression analysis revealed that use of

renin-angiotensin system inhibitors (OR: 2.22, 95% CI: 1.16

–

4.89, P = 0.02), urinary ACR (OR: 1.01, 95% CI: 1.00

–

1.01, P < 0.01)

and serum HDL-cholesterol concentration (OR: 0.33, 95% CI:

0.11

–

0.89, P = 0.03) were significantly associated in albuminuric

patients. Diabetic vascular complications occurred with sig-

nificantly higher frequency in the high urinary L-FABP group

than in the normal urinary L-FABP (

≤

8.4 μg/gCr) group among

the albuminuric patients. In the follow-up observation, the

change in urinary L-FABP was found to be significantly

(P < 0.01) influenced by the change in the HbA1c level in both

the normoalbuminuric (n = 396, r2 = 0.05, P < 0.01) and albumi-

nuric (n = 247, r2 = 0.06, P < 0.01) patients. The change in

urinary L-FABP was not significantly associated with the

changes in systolic blood pressure (n = 400, r2 = 0.005, P = 0.18)

and eGFR (n = 403, r2 = 0.004, P = 0.23) among the normoalbu-

minuric patients.

Conclusions:

Our results suggest that high urinary L-FABP is

associated with current metabolic abnormalities, including

high levels of HbA1c and systolic blood pressure among

normoalbuminuric patients with type 2 diabetes. The study

also indicates that diabetic vascular complications are

more frequent among albuminuric patients with high urinary

L-FABP.

PE-14

Carotid extra-media thickness is associated with intima-

media thickness and renal dysfunction in Korean patients

with type 2 diabetes

Jang Yel SHIN

Yonsei University, Wonju College of Medicine,

Korea

Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65

–

S211

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