Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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retinopathy among diabetic and prediabetic individuals were
1.7 (95%CI: 0.9, 3.2) and 1.3 (95%CI: 0.9, 2.1). Retinopathy was
observed in 34 (17.0%) of those remaining prediabetic and 18
(9.2%) of whose remaining NGT during the 4-year follow-up.
Compared to individuals who remained NGT, those who
remained prediabetic for 4 years were 2 (95% CI: 1.1, 3.7)
times more likely to have retinopathy; but the risk became
lower (OR = 0.9, 95% CI: 0.5, 1.9) after adjusting baseline age,
sex, BMI, hypertension.
Conclusions: Although risk of retinopathy seemed higher in
prevalent and long-term prediabetic state than NGT, but no
significant association were found between them. Other
baseline risk factors, such as hypertension, may play more
important role in the relationship with retinopathy.
PE-03
Risk factors of arterial stiffness in patients with type 2 diabetes
Yi-Mei WANG 1*, Wen-Jane LEE2, Wayne H.-H. SHEU3.
1 Department of Neurology, National Taiwan University Hospital,
Yun-Lin Branch, 2Department of Medical Research, Taichung
Veterans General Hospital, 3Division of Endocrinology and
Metabolism, Department of Internal Medicine, Taichung Veterans
General Hospital, Taichung, Taiwan
Background: Cardiovascular disease (CVD) is the main causes
of death in type 2 diabetes mellitus patients (T2DM). Early
identifications of those diabetes individuals at high risk for
CVD with subsequent interventions are important.
Objective: Brachial-ankle pulse wave velocity (baPWV), a
known indicator of arterial stiffness, is an independent
predictor of cardiovascular morbidity and mortality. We
investigate the determinants of cardiovascular risk factors
from measurements of baPWV in patients with T2DM.
Methods: This was a cross-sectional study with 93 T2DM
subjects who had no apparent history of CVD were enrolled.
After accurate clinical examinations and biochemical evalua-
tions, the enrolled subjects underwent baPWV examinations
by using VP-1000 Automatic Arteriosclerosis Measurement
System.
Results: The mean age of T2DM subjects was 61.5 ± 7.8 years
and the mean duration of diabetes was 11.7 ± 6.9 years. The
mean baPWV valuewas 15.5 ± 2.0 m/s. We found that values of
baPWV had statistically significantly correlations with the age
(r = 0.389, p = 0.001), bodymass index (BMI) (r = −0.194, p = 0.06),
duration of diabetes (r = 0.278, p = 0.007), regular exercise
(r = 0.219, p = 0.03), heart rate (HR) (r = 0.231, p = 0.03), systolic
blood pressure (SBP) (r = 0.571, p < 0.001), diastolic blood
pressure (DBP) (r = 0.405, p < 0.001), pulse pressure (PP) (r =
0.459, p < 0.001), mean arterial pressure (MAP) (r = 0.573, p <
0.001), hemoglobin (Hb) (r = −0.184, p = 0.08), hemoglobin
A1c (HbA1c) (r = 0.455, p < 0.001), creatinine (cre) (r = 0.361,
p < 0.001), albumin (r = −0.192, p = 0.07), homocysteine (Hcy)
(r = 0.255, p = 0.01), D-dimer (r = 0.301, p = 0.003), fibrinogen
(r = 0.277, p = 0.007), tissue inhibitor of metallopeptidase
inhibitor 1 (TIMP-1) (r = 0.364, p = 0.003), plasminogen activator
inhibitor-1 (PAI-1) (r = −0.228, p = 0.03), and urine albumin-
creatinine ratio (UACR) (r = 0.508, p < 0.001). In a multiple linear
regression analysis, age (95% CI: 0.011 –0.106; p = 0.02), HR (95%
CI: 0.009–0.073; p = 0.01), MAP (95% CI: 0.048–0.107; p < 0.001),
fibrinogen (95% CI: 0.001 –0.014; p = 0.03), TIMP-1 (95% CI:
0.0001 – 0.007; p = 0.04), and PAI-1 (95% CI: −0236 to − 0.202;
p = 0.02) were independently associated with levels of baPWV
in T2DM after adjustment of confounding risk factors.
Conclusions: These results suggest that older age, higher HR,
BP, fibrinogen, TIMP-1, and lower PAI-1 are associated with
levels of baPWV in T2DM subjects without CVD.
PE-04
Cases of diabetes complicated by sexual dysfunction
Shu Fen WANG 1*, Nai Ying KO2. 1No.901, Zhonghua Rd.,
Yongkang Dist., Tainan City, 2No.1, Ta-Hsueh Road, Tainan, Taiwan
Objectives: There are 371 million patients of diabetes in the
world. The overall prevalence of sexual dysfunction among
diabettics is 13.3–90%. Sexual dysfunction is the common
problem caused by diabetes. Sexual health is part of care for
patients. However, it tends to be neglected and it results in low
self-esteem and impact on quality of life. The current study
aimed to analyze case of diabetes complicated by sexual
dysfunction.
Methods: With diabetes for 11 years, the 40-year-old unmar-
ried male in a medical center in southern Taiwan has suffered
from erectile dysfunction, resulting in anejaculation even after
masturbation. Although the patient experiences an orgasm,
has sexual fantasies, and masturbates for two to three times
a week (had masturbated two times a day once), he has
been suggested taking Viagra while having checkups in the
urological department. Data collection included Arizona
Sexual Experience Scale (ASEX-CV), previous medical history,
medication use, chart review, and in-depth interview.
Results: The evaluation score of ASEX-CV was 26 and the
scores of penis erection and ejaculation satisfaction were both
six, thus revealing the participant’s erectile dysfunction and
anejaculation. The participant did not understand the rela-
tionship between diabetes and sexual dysfunction, feeling that
life would be meaningless without sex.
Conclusions: Diabetes and sexual function are closely related
and the prevalence is very high. What matters is not just cure,
but the prevention of sexual dysfunction related to diabetes.
The results revealed the close relationship between diabetes
and sexual functions.
PE-05
To prevent hemo-dialysis therapy due to diabetic
nephropathy. High-risk approach or population approach?
From doctors’ association ’s point of view
Hitomi FUJII1,2*, Nozomi AKASHI2, Makoto KUROISHIKAWA2,
Eitaro KODANI2, Hajime SASABE2, Hiroyuki NAKAMURA2,
Satoshi HONJO2, Toshiki WATANABE2, Shinichi TACHIKAWA2,
Isao INO3, Takaichi MIYAKAWA1,2, Yutaka TAMURA2.
1Tama-City Mirai Clinic, 2Tama-City Medical Association,
3Tama-City Division of National Health Insurance and Pension, Japan
Concerning about rapid-aging society in Japan, national and
local governments are concentrating on how to reducemedical
cost. To reduce high cost of starting and sustaining hemo-
dialysis, high-risk approach has been proposed for people
found as diabetes kidney disease by annual checkup held by
national insurance. Population approach for “metabolic syn-
drome” has been done for years by local government and
private sectors. The target was citizens who did not have
“home doctors” to visit regularly. And the purpose was to
prevent them from the onset of diabetes and atherosclerotic
disease.
However, at this moment, diabetes patients with nephropathy
already progressed and already visit their home doctors
regularly are the target.
Objective and Methods: To summarize three years of preven-
tion program of deterioration of diabetic nephropathy that has
been held by Tama-city and cooperation of doctors association
in Tama-city. Analyzing data of pre- and post-program and
compared between participants and non-participants.
Results: Body weight and blood pressure improved after the
program. HbA1c improved among poor control group. Non-
participants who rejected to participate the program tended to
have more proteinuria, more female smokers, and less
repeaters of annual checkup. However the data themselves
were not different between participants and non-participants.
Discussion: As local government and doctors’ association,
how to efficiently contribute for people’s health was the main
point of discussion. The local government started to dig up
people who never coming to checkups or who do not have
“home doctors ” even they received recommendation of
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S132