Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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we conducted a new-user, active-comparator, retrospective
observational study in the diabetes centre of our hospital,
between 1 May and 31 Dec 2014, to evaluate the effectiveness
and safety of canagliflozin in a real-world setting when
compared to Sitaglitin. This study had shown that there was
significant reduction in estimated glomerular filtration rate
(eGFR), up to 24 weeks of follow-up for the canagliflozin group.
Objective: The aim of this study was to extend our observa-
tions in patients on canagliflozin up to 52 weeks to further
evaluate the changes in eGFR.
Method: The renal profile of the patients aged 18–69 years with
type 2 diabetes and eGFR ≥ 60 mL/min/1.73 m2 who were
initiated on once daily canagliflozin 300 mg in the earlier
study were follow-up subsequently up to 52 weeks. The
changes in eGFR were measured and compared between the
baseline and up to 26 weeks of follow up.
Results: Data from a total of 22 patients who were initiated
on canagliflozin 300 mg with follow-up till 52 weeks were
included. When compared to baseline eGFR, we observed a
significant reduction in eGFR ( − 9.00 ± 10.04 mL/min/1.73 m2,
p = 0.002) up to 26 weeks of follow up. However, the reduction
in eGFR was not sustained up to 52 weeks of follow up
( −2.08 ± 5.33 mL/min/1.73 m2, P = 0.185)
Conclusion: The observations suggest that there is short term
reduction in eGFR with patients newly initiated on canagli-
flozin and these changes stabilized or attenuated over time in
patients with T2DM with initial function.
PD-91
Self-monitoring of blood glucosewith smart-phone based data
sharing improved glycemic control in patients with diabetes
Jun-Sing WANG 1, Yi-Jen HUNG2, An-Tsz HSIEH3, Ting-I LEE4,
Chih-Hsun CHU 5, Wayne H-H SHEU1*. 1Division of Endocrinology
and Metabolism, Department of Internal Medicine, Taichung
Veterans General Hospital, Taichung, 2Division of Endocrinology and
Metabolism, Department of Internal Medicine, Tri-Service General
Hospital, Taipei, 3Division of Endocrinology and Metabolism,
Department of Internal Medicine, Taipei Medical University – Shuang
Ho Hospital, New Taipei City, 4Division of Endocrinology and
Metabolism, Department of Internal Medicine, Wan Fang Hospital,
Taipei Medical University, Taipei, 5Division of Endocrinology and
Metabolism, Department of Internal Medicine, Kaohsiung Veterans
General Hospital, Kaohsiung, Taiwan
Background: The advance in mobile technology enables new
care models for patients with chronic diseases. We investi-
gated the effects of self-monitoring of blood glucose (SMBG)
with smart-phone based data sharing on glycemic control in
patients with diabetes.
Materials and methods: Adult patients with diabetes who had
inadequate glycemic control, defined as having a glycosylated
hemoglobin (HbA1c) >7%, were eligible. Patients were
instructed how to do SMBG and upload data with smart
phone using Health2Sync Mobile App. Patients were encour-
aged to have food diary using the established items in the App.
The diabetes educators reviewed the massages from patients
and replied as needed. The glucose values patients uploaded
were analyzed to investigate the changes in glycemic control
every two weeks up to week 18. The patients who uploaded
less than four glucose values every 2 weeks were excluded
from the analysis.
Results: From Sep 2014 to Feb 2016, a total of 186 patients with
diabetes were recruited from five hospitals. The number of
patients who uploaded at least four glucose values at week 0–2,
3 – 4, 5–6, 7–8, 9– 10, 11–12, 13 –14, 15 –16, and 17–18 was 186, 159,
146, 132, 112, 100, 90, 82, and 78, respectively. The median
number of glucose values uploaded every 2 weeks was 25–29
(i.e. around 2 tests per day). Overall, the mean glucose value
improved significantly from 177 ± 53 mg/dL at week 0–2 to
164 ± 52 mg/dL at week 3–4, and thereafter (all p values <0.05
compared with week 0–2). The percentage of glucose value
>180 mg/dL significantly decreased from 36.9 ± 26.0% at week
0–2 to 30.4 ± 25.4% at week 3–4, and thereafter (all p values
<0.05 compared with week 0–2). The percentage of glucose
value <70 mg/dL did not change significantly (5.2 ± 8.3% at
week 0– 2 and 7.9 ± 11.5% at week 17–18). We further analyzed
the glucose values in different daytime periods. We found that
the improvement in mean glucose was accompanied with an
improvement in postprandial glucose after breakfast and
lunch, but not after dinner.
Conclusions: Results from this study suggested that SMBG
combined with smart-phone based data sharing improved
glycemic control in patients with diabetes. Our results need to
be confirmed in future studies with an appropriate control
group.
PD-92
The impact of CGMS in subjects of inadequately controlled
type 2 diabetes under intensive glycemic control
Su-Chiung LIN1, Shi-Yu CHEN1, Yi-Jen HUNG2,
Chang-Hsun HSIEH2*. 1Department of Nursing, Tri-Service General
Hospital, 2Division of Endocrinology and Metabolism, Tri-Service
General Hospital, Taiwan
Background: The study is to evaluate the effect of continuous
glucose monitoring system (CGMS) intervention among
patients of poorly controlled type 2 diabetes (T2D) with
intensive insulin therapy.
Materials and methods: This is case-control study with
enrollment of a total of 40 subjects divided to 2 groups with
inadequately controlled T2D. The subjects with ongoing twice
daily pre-mixed insulin therapy with glycated hemoglobin
(A1C) greater than 8% were enrolled and all switched to pre-
mixed insulin therapy three times per day for three months.
The case group appliedCGMS before and after intensive insulin
therapy. The difference of A1Cwas compared between 2 groups
to explore the benefit of intervention of CGMS. The change of
index of glucose variability in the case group before and after
intensive insulin therapy was also evaluated.
Results: The mean age of the subjects was 47 y/o with mean
duration of 9.4 years. Both groups show significant reduction
of A1C (9.4% to 8.3%, and 9.3% to 8.6%, both with p < 0.001).
Moreover, the case group with CGMS intervention showed
greater A1C reduction than that of control group (−1.1% vs
−0.7%, p < 0.001). The index of glucose variability demon-
strated improvement of mean amplitude of glucose excursions
(124 mg/dL to 92 mg/dL, p < 0.001), and standard deviation
(63 mg/dL to 44 mg/dL, p < 0.001) by introduction of CGMS with
receiving intensive insulin therapy.
Conclusion: The present study confirmed the benefit of
CGMS intervention in improvement of glucose variability and
glycemic control in subjects of inadequately controlled type 2
diabetes.
PD-93
Dietary patterns influence blood sugar and lipid control
among type 2 diabetic patients in Taiwan – A pilot study
Min-Su TZENG1*, Yi-Cih HONG1, Ching-Chu CHEN2,
Chwen-Tzuei CHANG2, Mei-Due YANG3, Meng-Chun LU3.
1Department of Nutritional Science, Fu-Jen Catholic University, New
Taipei City, 2Division of Endocrinology & Metabolism, Department of
Internal Medicine, China Medical University Hospital, 3Department
of Clinical Nutrition, China Medical University Hospital, Taichung,
Taiwan
The prevalence of Diabetes Mellitus has increased from4.8% to
7.1% within five years since 2007. Research showed that
changing eating habits may be one of the most effective
therapies to treat diabetes. However, dietary patterns among
Taiwanese diabetic patients are rarely studied. The objectives
of present study were to explore what dietary patterns among
diabetic patients and their odds ratios of blood sugar and lipids
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S120