Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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liraglutide (Lira) or the short-acting GLP-1RA lixisenatide (Lixi)
in Japanese patients with type 2 diabetes. Plasma glucose,
insulin, and glucagon were measured using blood sampling
and gastric emptying was measured using 13C breath test for
4hours after solid test meal (280 kcal carbohydrate, 100 kcal
protein, 100 kcal fat and 13C-sodium acetate 200 mg). Areas
under the curve (AUC) of plasma glucose, insulin and glucagon
were calculated using trapezoidal rule. Gastric emptying rate
(T1/2) was analyzed based on the time-plot of pulmonary
13CO2 excretion rate (% dose/h) according to the Wagner-
Nelson method. Data (mean ± SEM) were evaluated using
student’s t-tests or paired t-test. p < 0.05 was considered
significant.
Results: Before initiation of the GLP-1RA agents, there were no
significant differences in HbA1c, BMI or duration between Lira
and Lixi groups (Lira, n = 10; age 55.2 ± 3.0 year old; duration
9.2 ± 2.7 years/ Lixi, n = 5; age 52.4 ± 3.9 year old; duration
10.2 ± 4.2 years). After 12 wks administration of maximum
dose agents (Lira 0.9 mg/Lixi 20 ug in Japan), HbA1c and
bodyweight were significantly improved in both Lira and Lixi
groups (HbA1c(%): Lira, 8.7 ± 0.3 to 6.8 ± 0.3; Lixi, 9.2 ± 0.8 to
7.4 ± 0.8/BMI(kg/m 2): Lira, 28.4 ± 1.2 to 27.1 ± 1.1; Lixi, 30.0 ± 2.2
to 28.8 ± 2.0). Gastric emptying was delayed in Lixi but not in
Lira group (T1/2 (min): Lira, 31.3 ± 4.6 to 26.9 ± 2.9 min; Lixi,
23.3 ± 0.9 to 53.8 ± 12.1). Postprandial insulin secretion was
significantly enhanced in Lira but not in Lixi group (IRI-
AUC0-240 (uIU/dL·min): Lira, 7886 ± 1568 to 10883 ± 2101; Lixi,
5971 ± 1677 to 5653 ± 1255). Postprandial glucagon secretion
was not significantly changed in Lira or Lixi group (IRI-AUC0-
240 (uIU/dL·min): Lira, 22861.4 ± 2153.8 to 22340.7 ± 4222.3; Lixi,
24260.0 ± 4563.6 to 23911.3 ± 6762.8).
Conclusion: These results partially support the notion
that long-acting agents improve glycemic control through
enhanced insulin secretion and that short-acting agents do so
through delayed gastric emptying.
PD-107
The efficacy of liraglutide for treatment of type 2 diabetes
Hung-Ling SU 1*, Shin-Li SU 2, Shang-Ren HSU2, Shin-Te TU2,
Ming-Chia HSIEN 2, Hui-Fang WANG1, Ya-Yu TSENG1,
Chiao-Yun CHEN 1, Sin-Huei WU1, Pei-Shiuan SHEN1,
Chun-Chun YAU 1, Hsiang-Ju CHEN1. 1Diabetes Center, Changhua
Christian Hospital, 2Endocrinology, Changhua Christian Hospital,
Taiwan
Background: Besides control of hyperglycemia, treatment of
type 2 diabetes with liraglutide is advantageous for its weight-
reducing effect and lack of hypoglycemic risk. As liraglutide
has been introduced in Asia only in recent years, treatment
experience has been relatively lacking in Asian countries.
Purpose: To investigate the efficacy of liraglutide in the
treatment of type 2 diabetic patients in Taiwan.
Methods: This is an observational study conducted in a
medical center in central Taiwan. Subjects were randomly
selected from type 2 diabetic patients who visited the
metabolism clinics of the medical center between 1 March,
2013 and 31 March, 2016.
Result: A total of 184 subjects, including 86 men (46.75%) and
98 women (53.3%) were included. Mean age was 52.97 ± 12.26
years and mean duration of diabetes 12.20 ± 9.25 years.
Subjects were treated with liraglutide for a mean duration
of 16.13 ± 11.95 months, predominantly with a dosage of
1.2 mg/day. At one year after treatment, there were significant
reductions in weight, body mass index, waist circumference,
glycated hemogloblin level, and fasting blood glucose (p <
0.001). However, at two years none of these parameters had
significant change.
Conclusion: Liraglutide had significant efficacy within one
year of treatment. After one year, additional therapeutic
measures may be required to achieve further metabloic
improvement.
PD-108
Beneficial effect on postprandial glucose excursion by
ingestion of boiled barley rice and Japanese side dishes
Yoko TANEMURA1*, Takashi SASAKI2, Tomoko ISHIZAKI3,
Megumi SOTOME4, Akihiko HOSODA5, Yoshiyuki SHINODA3,
Atsumi OGAWA3, Sadanori AKAISHI5, Ai YUASA1,
Munehiro ONUMA4, Susumu HAYASHI5, Hironobu HAMA3.
1The Jikei University Katsushika Medical Center, 2The Jikei University
School of Medicine, 3The Jikei University Hospital, 4The Jikei
University Daisan Hospital, 5The Jikei University Kashiwa Hospital,
Japan
Suppression of postprandial excursion in plasma glucose level
might be important for the prevention and treatment of type 2
diabetes. In Japan, white rice is an indispensable staple food
but it leads relatively high postprandial glucose excursion by
its high glycemic index (GI). Avoiding hard texture of barley
and taking advantage of its lower GI, white rice cooked by
mixing 30% with barley, boiled barley rice, would be easier to
ingest and could lower postprandial glucose level. In this
study, we aimed to investigate the effect of combined
ingestion of boiled barley rice with Japanese side dish contain-
ing mainly protein on postprandial glucose level.
The study was conducted in a randomized crossover design for
six kinds of test meals on 19 Japanese healthy volunteers (M:F,
10:9; mean age ± SD at the baseline, 38.0 ± 7.3 years; BMI,
21.5 ± 1.9 kg/m2). Each test meal contained 50 g of available
glucide. The test meal combination were as follows; white rice
(Koshihikari, R) alone, boiled barley rice (B) alone, R or B with
side dish of protein source containing each of grilled fish
(mackerel, Fi), chicken hamburg steak (Ch), boiled egg (Eg)
or fermented soybeans (Natto, Na). Plasma glucose levels
were examined at fasting (0), 30, 45, 60, 90 and 120 min after the
start of meal load to calculate the area under the curve.
Statistical analysis was performed with Friedman multiple
comparison test.
Although peak plasma glucose level of B was tend to be lower
than that of R, no significant difference was observed between
AUC of white rice alone (AUC_R, 4,904 ± 1,549 mg/dL*min) and
AUC_B (3,722 ± 1,214 mg/dL*min), p = 0.170. In the analysis of
AUCs after themeal load combinedwith side dishes, AUC_RCh
(2,492 ± 942 mg/dL*min), AUC_REg (2,910 ± 1,439 mg/dL*min)
and AUC_RFi (2,345 ± 1,258 mg/dL*min) were significantly
lower than AUC_R (p < 0.01, p = 0.01 and p = 0.02, respectively).
AUC_BCh (2,241.0 ± 765 mg/dL*min), AUC_BEg (2,489 ± 834 mg/
dL*min) and AUC_BFi (2,023 ± 1,167 mg/dL*min) were all even
lower than AUC_R significantly (p < 0.01). When compared to
AUC_B, on the other hand, AUC_BCh and AUC_BFi were
significantly low (p < 0.01). AUC_RCh and AUC_RFi were still
lower than AUC_B significantly (p < 0.01). No significant
difference, however, were observed between AUC_R and
AUC_RNa (2,881 ± 977 mg/dL*min). Conclusively, combined
ingestion of boiled barley rice and Japanese food side dish
might improve postprandial excursion in plasma glucose level.
PD-109
Efficacy and safety of gemigliptin as add-on therapy in patients
with type 2 diabetes inadequately controlled on metformin
and glimepiride
Kyung Ah HAN1, Jae Myung YU2, Hak Chul JANG3,
Young Duk SONG4, Kyu Jeung AHN5 , Takkeun OH6,
Hyoung Woo LEE7, Daeho LEE8, Jae Taek KIM9,
Choon-hee JEONG10, Byoung-joon KIM11 , Kyong Soo PARK12 *.
1Eulji General Hospital, 2Kangnam Sacred Heart Hospital, 3Seoul
National University Bundang Hospital, 4National Health Insurance
Corporation Ilsan Hospital, 5Kyung Hee University Hospital at
Gangdong, 6Chungbuk National University Hospital, 7Yeungnam
UniversityMedical Center, 8Wonkwang University School of Medicine
and Hospital, 9Chung Ang University Hospital, 10Chonbuk National
University Hospital, 11Gachon University Gil Medical Center, 12Seoul
National University College of Medicine, Korea
Poster Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S65–S211 S125