Diabetes Research and Clinical Practice - Volume 120 - Supplement 1

(7.89 ± 2.77)] mmol/L. In generalized linear model, baseline

uACR (B = 0.412, p = 0.044) and SBP (B = 0.021, p = 0.032)

remained significant independent predictors of future risk of

DPN, after adjustment for age, gender, ethnicity, eGFR, PWV

and duration of diabetes.

Conclusion:

In patients with T2D followed up for 3 years,

baseline uACR and blood pressure are significant predictors of

incident DPN. While our data allows identifying patients at risk

of future DPN, further studies are needed to see if improve-

ments in these predictors will result in lower incidence of DPN.

OL07-7

Relationship between blood neutrophil

–

lymphocyte ratio and

chronic kidney disease in overweight and obese adult

population

Yi-Ting TSAI

, Yu-Hsuan LI

, Ya-Yu WANG

–

Wayne H-H SHEU

1,4

, Yuh-Min SONG

, Shih-Yi LIN

1,4,5

Wen-Dau CHANG

Division of Endocrinology and Metabolism,

Department of Internal Medicine, Taichung Veterans General

Hospital,

Department of Family Medicine, Taichung Veterans

General Hospital,

Department of Veterinary Medicine, College of

Veterinary Medicine, National Chung Hsing University, Taichung,

School of Medicine, National Yang Ming University, Taipei,

Center

for Geriatrics and Gerontology, Taichung Veterans General Hospital,

Taichung, Taiwan

Background:

Obesity-associated inflammation has a potential

role in the pathogenesis of chronic kidney disease (CKD).

Neutrophil-to-lymphocyte ratio (NLR) is increasingly recog-

nized as a marker of systemic inflammation. We investigated

the association between NLR and renal function in an adult

population.

Methods:

For cross-sectional study, 2965 apparently healthy

adults (1824 men and 1141 women) who attended health exa-

mination fromAugust 2000 to April 2002 at a medical centre in

central Taiwan were included. We collected anthropometric

measurements, fasting blood test results, lifestyle habits and

medical history. Renal insufficiency (RI) was defined as esti-

mated glomerular filtration rate (eGFR) <60 mL/min/1.73 m

calculated by using the CKD-EPI equation. Body mass index

(BMI) was calculated by dividing body-weight by the square of

height (kg/m

). Weight status was categorized according to the

criteria of the Ministry of Health and Welfare, Taiwan.

Results:

There were 485 obese participants (BMI

≧

27, M:

F = 342:143), 942 overweight participants (24

≦

BMI < 27, M:

F = 676:266), and 1538 normal weight or underweight partici-

pants (BMI <24, M:F = 806:732). Higher prevalence rates of RI

were observed in obese and overweight participants, com-

pared to participants with BMI < 24, in women (14.7% vs. 9.4%

vs. 5.7%, p for trend = 0.0001) but not inmen (14.4% vs. 14.4% vs.

15.8%, p for trend = 0.602). In overweight and obese partici-

pants, multivariable logistic regression analysis revealed that

higher NLR (per 1 unit) was independently associated with

higher risk of RI in both women [OR = 1.85 (95% C.I.: 1.16

–

2.97),

p = 0.010] and men [OR = 1.41 (95% C.I.: 1.08

–

1.84), p = 0.013],

after adjusting for age, BMI, smoking, alcohol consumption,

systolic blood pressure, total cholesterol, triglyceride, HDL-

cholesterol, fasting plasma glucose, and serum total bilirubin.

Conclusions:

In both men and woman with BMI

≧

24, higher

NLR was associated with higher risk of RI. As NLR is an

inexpensive and readily availablemarker, it may be potentially

useful for CKD risk assessment in overweight and obese

populations.

OL07-8

The risk factors for asymptomatic pyuria among the patients

with type 2 diabetes

Yoko WARAGAI

, Akahito SAKO

*, Tadayuki KONDO

Yu TAKEUCHI

, Hidekatsu YANAI

Department of Internal

Medicine, Kohnodai Hospital, National Center for Global Health and

Medicine,

Department of Psychiatry, Kohnodai Hospital, National

Center for Global Health and Medicine, Japan

Introduction:

Although urinary tract infections are common in

diabetic patients, there have been only a few studies that

investigated the relationships of pyuria in type 2 diabetic

patients with patient background, laboratory data and dia-

betes complications. We aimed to elucidate the risk factors for

asymptomatic pyuria among the patients with type 2 diabetes.

Methods:

We retrospectively investigated the patients with

type 2 diabetes who visited the Department of Internal

Medicine because of diabetes for the first time from

December 2010 to November 2012. The study protocol was

approved by institutional review board. We excluded the

patients who had cystitis or pyelonephritis or who had

antibiotics within 1 month. We collected the information

about patient characteristics, laboratory data, and diabetes

complications. We examined the coefficient of variation of R-R

interval (CVR-R) of electrocardiogram for the evaluation of

autonomic function. Pyuria was defined as the presence of

more than 10 leucocytes/High Power Field in a random urine

sample. We used t-test and chi-square test to compare the

variables between patients with and without pyuria. Values

were expressed as mean ± Standard Deviation.

Result:

Among 121 eligible cases, 52 cases were female. Mean

age, BMI, and duration of diabetes were 63.2 ± 13.4 years old,

26.0 ± 5.7 kg/m

, and 5.1 ± 7.5 years, respectively. Forty-eight

cases had mental illness. Mean HbA1c, plasma glucose, and

CVR-R were 8.5 ± 2.1%, 195 ± 95 mg/dL and 3.0 ± 2.0%, respect-

ively. Pyuria was found in 19 cases (16%). Prevalence of pyuria

was significantly higher in female than male (30.8 vs 4.3%).

Patients with mental illness had significantly higher preva-

lence of pyuria than those without mental illness (25.0 vs

9.6%). Patients with pyuria had significantly lower mean CVR-

R than those without pyuria (1.8 ± 1.1% vs 3.2 ± 2.0%). In the

sub-analysis limited to female, mental illness and lower CVR-

R were significantly associated with the presence of pyuria.

Age, HbA1c, retinopathy were not associated with pyuria.

Conclusion:

In addition to female sex, the presence of mental

illness, and low CVR-R values were significantly associated

with the asymptomatic pyuria in diabetic patients. We need to

carefully manage these patients for the risk of urinary tract

infections.

Nutrition, Diabetes Education and

Management Systems

OL08-1

Whole grain intakes are associated with better ABC control in

patients with type 2 diabetes in Taiwan

Hsiu-Yueh SU

, Min-Su TZENG

, Shu-Ti CHIOU

Neng-Chun YU

, Wayne H-H SHEU

Department of Dietetics,

Taipei Medical University Hospital,

Department of Nutritional

Science, Fu Jen Catholic University,

Health Promotion

Administration, Ministry of Health and Welfare,

Yu Neng-Chun

Diabetes Clinic, I-Lan County,

Division of Endocrinology and

Metabolism, Department of Internal Medicine, Taichung Veterans

General Hospital, Taiwan

To study the association of whole grain intake with ABC

control in patients with type 2 diabetes, a cross-sectional

survey by using food frequency questionnaire was conducted

2011 in Taiwan. A total of 677 adults type 2 diabetes were

enrolled. Whole grain included brown rice and mixed grains,

and participants reported the intake frequency and the

amount of whole grains, including brown rice and mixed

grains, during the past month on a daily, weekly, andmonthly.

Whole grain group was defined as intake of one of the brown

rice or mixed grains at least once a day and no whole grain

group was less than once a day. Only one third of diabetes

patients (n = 214) ate at least once a day whole grain (31.6% vs

Oral Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S40

–

S64

S57