Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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meta-analysis reported that central arterial pressure can be a
more useful predictor of cardiovascular disease. Postprandial
metabolic and hemodynamic responses are not fully studied.
We aimed to examine the changes and associations between
central BP and insulin sensitivity during an oral glucose
tolerance test (OGTT).
Research design and methods: Subjects without diabetes
history underwent a 75-g OGTT from November 2011 to June
2015 while those taking anti-hypertensive medications were
excluded. A validated oscillometric BP monitor was used to
measure and calculate brachial systolic BP (SBP-b), brachial
diastolic BP (DBP-b), central SBP (SBP-c) and central DBP (DBP-c)
at the timings of 0, 30 and 120 min, respectively, during
the OGTT while plasma glucose and insulin concentrations
were measured at these timings. Percentage of each change
(presented as % Δ) after OGTT was calculated by subtracting
pre-OGTT measurement as (post-OGTT −pre-OGTT)/pre-
OGTT. The relationships between changes in BP and glucose
andMatsuda insulin sensitivity index (ISIM) during OGTTwere
analyzed.
Results: Sixty-four adults (43 men and 21 women, mean age of
56 ± 14 years) were enrolled and baseline (0 min) SBP-b, DBP-b,
SBP-c, DBP-c were 122 ± 11, 74 ± 8, 120 ± 11, and 69 ± 7 mmHg,
respectively. Fasting glucose was 93 ± 11 mg/dL. Percentage
change of glucose at 30 min (%ΔGlu 30′) negatively correlated
to % ΔSBP-b 120′ (r = −0.367, p = 0.003) and %ΔSBP-c 120′ (r =
− 0.283, p = 0.02), respectively. In addition, the more SBP-c
increment from 0 ′ to 30 ′ (%ΔSBP-c 30′), the higher log-trans-
formed ISIM was measured (r = 0.265, p = 0.03). Results of
multivariable linear regression analysis, adjusted of age, sex,
body mass index, smoking status, heart rate and glucose
tolerance status, identified % ΔSBP-c 30′ but not %ΔSBP-b 30′
was an independent determinant of log-transformed ISIM
(p = 0.02, 95%, CI: 0.183–1.714).
Conclusion: Metabolic and hemodynamic responses including
BP, glucose and insulin sensitivity after an oral glucose loading
varied greatly. We present the subtle changes during short-
term postprandial phase that elevated SBP-c was associated
with one’s enhanced insulin sensitivity. The detailedmechan-
isms and long-term BP variability on cardiovascular outcomes
require further investigation.
OL01-5
High diagnosis lag in diagnosis of type 2 diabetes mellitus:
Need of the hour
Chandrasekhar BOYA1, Dipika BANSAL 2*. 1National Institute of
Pharmaceutical Education and Research, 2National Institute of
Pharmaceutical Education and Research, SAS Nagar, Punjab, India
Background and objectives: Type 2 Diabetes Mellitus is often
characterized by an asymptomatic phase of around 4 –7 years
between the onset of diabetes and its clinical diagnosis.
Diabetic retinopathy is the one to be observed as an early
sign of microvascular complications. The objective of the
present study is to investigate the time lag between the onset
of hyperglycemia and clinical diagnosis of T2DM.
Methods: The present cross-sectional study was done at an
outpatient setting of an endocrinology clinic. According to
inclusion criteria, Consecutive patients subjects of either sex
with T2DM either newly diagnosed at the time of first
encounter with study investigator or previously diagnosed
with any duration of T2DM were eligible to be recruited in the
present study. A weighted linear regression analysis was
performed to estimate the prevalence of retinopathy at each
time point. The period at which the prevalence of retinopathy
was zero is back extrapolated from the graph to get onset of
diagnosis.
Results and interpretations: A total of 1407 patients with
T2DM are included in present analysis. 52% (n = 725) were
females and mean (SD) age was 54.3 (10.1) years. The
prevalence of diabetic retinopathy was found to be 13.7%
(n = 194) at the time of clinical diagnoses. Prevalence of
retinopathy increased linearly with duration of T2DM.
Estimated the actual onset of time of diabetes was found to
be 11.4 (95% CI, 9.5–15) years before the patients were clinically
diagnosed with T2DM.
Conclusions: High diagnostic lag was observed in present
study. It indicates that there is a need for continues education,
counseling of high risk population on diabetes mellitus and its
complications to increase awareness of diabetes and reduction
of diagnostic lag.
OL01-7
The influence of oral contraceptives on the prevalence of
diabetes in postmenopausal women: 2007– 2012 KNHANES
Sung-Woo KIM1, Gwon-Soo JUNG2*, Jae-Han JEON2,
Jung Eun JANG2, Yeon-Kyung CHOI2 , Kwi-Hyun BAE2,
Jung-Guk KIM2, Keun-Gyu PARK2, In-Kyu LEE2. 1Department of
Internal Medicine, CHA GUMI Medical Center, Gumi 2Department of
Internal Medicine, Kyungpook National University School of
Medicine, Daegu, Korea
Background and aims: There is little information on whether
past use of oral contraceptives (OCs) at childbearing age
influences the incidence of diabetes and insulin resistance
(IR) after menopause. This study aimed to evaluate the
association of past use of OCs with the development of
diabetes and IR in post-menopausal women.
Materials and methods: This cross-sectional study was based
on data from the Korea National Health and Nutrition
Examination Survey from 2007 to 2012. Of the 50,405 partici-
pants, 6554 postmenopausal women were selected and
included in the analysis. The long-term effects of OCs use on
the prevalence of diabetes in post-menopausal women were
examined using multivariate logistic analysis. In addition,
fasting glucose and insulin levels were measured in 3338 non-
diabetic post-menopausal women, and the association
between IR and OCs was examined by analysis of covariance.
Results: The prevalence of diabetes was significantly higher in
post-menopausal participants who had taken OCs for more
than 6 months than in those who had never taken OCs. The
association remained significant after adjusting for multiple
confounding factors (odd ratio, 1.379; 95% CI, 1.115–1.707;
P = 0.003). The duration of OCs use was also positively
associated with the prevalence of diabetes. Furthermore,
taking OCs for more than 6months led to a significant increase
in fasting insulin levels and HOMA-IR in non-diabetic
participants.
Conclusion: Past use of OCs for more than 6 months led to a
significant increase in the prevalence of diabetes in post-
menopausal women, and increased IR in non-diabetes parti-
cipants. These results suggested that prolonged use of OCs at a
reproductive age is an important risk factor for developing
diabetes in post-menopausal women.
Pathogenesis of Obesity, Diabetes, and
Diabetic Complications
OL02-1
Possible role of hepassocin in chronic social defeat-induced
metabolic disturbance
Hung-Tsung WU1*, Horng-Yih OU2, Sheng-Feng TSAI3,
Yu-Min KUO4, Po-See CHEN5, Chih-Jen CHANG6. 1Research
Center of Clinical Medicine, National Cheng Kung University
Hospital, 2Department of Internal Medicine, National Cheng Kung
University Hospital, College of Medicine, National Cheng Kung
University, 3Institute of Basic Medical Sciences, College of Medicine,
National Cheng Kung University, 4Department of Cell Biology and
Anatomy, College of Medicine, National Cheng Kung University,
Oral Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S40–S64 S41