Diabetes Research and Clinical Practice - Volume 120 - Supplement 1 - October 2016

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with established CHD at baseline were significantly older, had
more male subjects, longer duration of diabetes, lower eGFR,
but had comparable HbA1c and % with retinopathy compared
to subjects without CHD. Subjects with CKD at baseline were
older, had longer duration of diabetes, had higher BMI, higher
HbA1c, lower eGFR, higher urine alb/creat ratio, and higher
percentage with retinopathy (all p < 0.001). Co-existing CHD
and CKD was present in 3.1% of subjects.
Conclusions: We have established a contemporary cohort and
biobank of Chinese patients with type 2 diabetes for epidemi-
ology research and biomarker discovery. This revealed an
alarmingly high prevalence of cardio-renal complications
among Chinese patients with type 2 diabetes. The identifica-
tion of risk factors and biomarkers associated with cardio-
renal complications may facilitate the early identification of
high-risk subjects.
Acknowledgment: Funded by a Theme-based Research
Scheme from the Research Grants Council of the Hong Kong
Administrative Region, China (Project no: T12-402/13-N)
OL03-6
The relation between urinary albumin excretion rate (AER) and
peripheral artery disease in Taiwanese diabetic patients
Ming-Chieh TSAI 1, Chun-Chuan LEE1*, Sung-Chen LIU1.
1 Department of Endocrinology, Department of Internal Medicine,
Mackay Memorial Hospital, Taipei Branch, Taiwan
Objective: We wanted to find out the relation between the
urinary albumin excretion rate (AER) and peripheral artery
disease in Diabetes Mellitus patients.
Methods: A total of 1233 diabetic patients whose age more
than 18 years old from outpatient clinic in single center
hospital were included. Peripheral artery disease was diag-
nosed as ankel branchial index (ABI) <0.9. Urinary albumin
excretion rate were divided into 3 groups, normal (AER < 30 μg/
mg), microalbuminuria (AER: 30–299 μg/mg) and macroalbu-
minuria (AER > 300 μg/mg). We had analysed the relation
between urinary albumin excretion rate and peripheral
artery disease in Taiwan diabetic patient by student T test
and logistic regression.
Result: There were 95 diabetic patients (male: 47, female: 46)
with peripheral artery disease and 1138 diabetic patients
(male: 525, female: 613) without peripheral artery disease.
Patients with peripheral artery disease had higher urinary
albumin excretion ratio (AER 560.68 μg/mg) than patient
without peripheral artery disease (AER 199.99 μg/mg)
(P = 0.014). The proportion of normal, microalbuminuria and
macroalbuminuria in diabetic patients with peripheral artery
disease was 43.5%, 28.2%, 28.2%, respectively, 65.7%, 23.2%,
11% in the diabetic patients without peripheral artery disease
(p < 0.001). The simple logistic regression analysis revealed Ln
AER significant associated with the mean of bilateral ABI with
a p value of 0.012 (β = − 0.074).
Conclusion: The correlation between urinary albumin excre-
tion rate (AER) and peripheral artery disease was significant.
Urinary albumin excretion rate could be a predict factor of
peripheral artery disease in diabetic patients.
OL03-7
Characteristics of Korean T2DM patients with diabetic
retinopathy and macular edema: A Study based on a
standardized clinical data
Sejeong PARK 1, Sang Youl RHEE1, Ki Young KIM 2, Yu Jin KIM1,
Suk CHON 1, Seung-Young YU 2, Young Seol KIM3,
Jeong-taek WOO 1*. 1 Department of Endocrinology and Metabolism,
Kyung Hee University School of Medicine, 2Department of
Ophthalmology, Kyung Hee University School of Medicine, Seoul,
3 Department of Internal Medicine, Chung Hospital, Seongnam, Korea
Objective: This study was carried out as a national project to
secure standardized biomedical resources of Korean subjects
with type 2 diabetes mellitus (T2DM). It was conducted as a
part of the Korea Biobank Project, which was launched by the
Korea National Institute of Health. It was designed as a
fundamental study to identify the clinical characteristics of
diabetic retinopathy and macular edema in Korean T2DM
patients.
Methods: From September 2014 to July 2015, in a single
university hospital in Korea, clinical data and samples were
collected prospectively from T2DM subjects whose duration of
DM was over 20 years. Data and samples were collected
according to the common data element and the standard of
procedure which was developed by the Korean Diabetes
Association research council for the standardization of
clinical data. The presence of diabetic retinopathy and
macular edema was evaluated with multi-field funduscopy
and optical coherence tomography performed by ophthalmo-
logic specialists.
Results: Among 198 patients enrolled in the first year of the
study, 183 patients completed the evaluation on diabetic
retinopathy and macular edema. Mean age of the participants
was 66.8 years, median duration of DM was 22.6 years, and
49.7%weremale. When the characteristics of the patients were
analyzed according to the presence of diabetic retinopathy and
macular edema, various clinical characteristics showed sig-
nificant difference between two groups. Age, fasting glucose
level, duration of T2DM, family history of chronic disease, use
of sulfonylureas or insulin were identified as independent risk
factors for DM retinopathy. Sex, age, height, weight, duration
of DM and the use of insulin were confirmed as independent
risk factors for macular edema.
Conclusion: In this study, we identified various clinical
features that are associated with the development of DM
retinopathy and macular edema. Additional longitudinal
observation and multi-omics based experiments are being
conducted to understand the pathophysiology of DM related
complications in Korean patients with T2DM.
OL03-8
A novel scoring system for detecting diabetic kidney disease
predicts renal function decline in patients with type 2 diabetes
Chih-Hung LIN1,2, Tzu-Ling TSENG3 , Wei-Ya LIN3,
Hsiang-Chi WANG3, Lee-Ming CHUANG1,2*. 1Graduate Institute
of Clinical Medicine, College of Medicine, National Taiwan University,
2Department of Internal Medicine, National Taiwan University
Hospital, Taipei, 3Bio Preventive Medicine Corp., Hsinchu, Taiwan
Background: Diabetic kidney disease (DKD) is one of the leading
causes of chronic kidney disease (CKD) and end-stage renal
disease (ESRD) worldwide. Despite being the diagnostic criteria
for DKD, the predictive value of urinary albumin-to-creatinine
ratio (UACR) on the progression toward advanced CKD is
limited, due to the heterogeneous disease nature. DN_Score is
a scoring systemgenerated fromtheprofiles of DNlite, aurinary
biomarker panel composed of alpha2-HS-glycoprotein precur-
sor (AHSG), alpha-1-antitrypsin (A1AT) and acid-1-glycopro-
tein (AGP). Cross-sectional study has shown significant
correlations between DN_Score and traditional indicators of
DKD. In this prospective cohort study, we evaluated the
potential of DN_Score for predicting decline of renal function
in patients with type 2 diabetes (T2DM).
Material and methods: 308 patients with T2DM were enrolled
in this study. Each participant was followed-up at 6-month
interval over a period of 2.5 years. Estimated glomerular
filtration rate (eGFR), UACR and DN_Score were recorded at
baseline and each visit.
Results: A total of 282 participants completed the 2.5-year
follow-up. With a baseline cutoff level of 11.4, the overall mean
difference in change of eGFR (%) in participants with the higher
and the lower DN_Score was −3.68 and 1.32, respectively
(between-group difference P < 0.01). In participants with base-
line eGFR < 60 mL/min/1.73 m2, DN_Score also predicted a
Oral Presentations / Diabetes Research and Clinical Practice 120S1 (2016) S40–S64 S47